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Agonist activity at human GPR119 expressed in HEK293S cells assessed as increase in intracellular cAMP level incubated for 45 mins by HTRF analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human GPR119 expressed in CHO-K1 cells assessed as increase in intracellular cAMP level incubated for 5 mins by fluorescence analysis
Agonist activity at human GPR119 incubated for 2 hrs by luciferase reporter gene assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of GPR119 (unknown origin) at 10 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
GPCR beta-arrestin recruitment assay with target: GPR119 Assay Type: PRESTO-Tango Concentration: 0.0000004
Assay data:211 Tested
SummaryRelated BioAssays by Target
GPCR beta-arrestin recruitment assay with target: GPR119 Assay Type: PRESTO-Tango Concentration: 0.000002
GPCR beta-arrestin recruitment assay with target: GPR119 Assay Type: PRESTO-Tango Concentration: 0.00001
Assay data:437 Tested
Agonist activity at human GPR119
Agonist activity at GPR119 (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
LANCE cAMP Assay from US Patent US9469631: "N-cyclopropyl-N-piperidinyl-amides, pharmaceutical compositions containing them, and uses thereof"
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
AlphaScreen cAMP Assay from US Patent US9469631: "N-cyclopropyl-N-piperidinyl-amides, pharmaceutical compositions containing them, and uses thereof"
Assay data:126 Active, 116 Activity ≤ 1 µM, 126 Tested
Tet-Inducible cAMP Assay from US Patent US9174965: "Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
AlphaScreen cAMP Assay from US Patent US8772323: "Benzoxazole- and tetrahydrobenzoxazole-substituted pyridazinones as GPR119 agonists"
Assay data:254 Active, 193 Activity ≤ 1 µM, 259 Tested
PRESTO-Tango GPCRome screening (GPR119)
Agonist activity at rat GPR119 in GLUTag cells assessed as induction of GLP-1 secretion after 2 hrs by ELISA
Agonist activity at rat GPR119 in golden hamster HIT-T15 cells assessed as induction of glucose-induced insulin secretion after 2 hrs by A1phaLISA
Agonist activity at rat GPR119 expressed in CHO cells co-expressing cyclic AMP response element-luciferase reporter gene incubated for 2 hrs by steady-glo luciferase assay
Agonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element-luciferase reporter gene incubated for 2 hrs by steady-glo luciferase assay
Assay data:20 Active, 19 Activity ≤ 1 µM, 21 Tested
Antagonist activity at GPR119 (unknown origin) at 10 uM
Agonist activity at GPR119 (unknown origin) at 10 uM
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