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Inhibition of recombinant FLAG-tagged human dicer expressed in HEK293 cells assessed as reduction in pre-let-7g microRNA maturation at 5 to 10 uM after 40 mins by SYBR green2 dye based fluorescence assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to dicer (unknown origin) assessed as inhibition of dicer-meditated pre-let-7d microRNA maturation at 100 uM by electrophoretic mobility shift assay
Assay data:2 Tested
Effect on Dicer (unknown origin) assessed as effect on 5'-gamma32P-ATP labeled pre-miRNA processing at 5 uM after 15 mins by gel electrophoresis assay
Inhibition of human recombinant Dicer-mediated pre-miR-29a processing assessed as reduction of mature miR-29a formation at 200 uM after 3 hrs by Northern blot analysis
Assay data:2 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human recombinant Dicer-mediated long dsRNA digestion assessed as 21- to 23-mer short RNA formation at 200 uM after 3 hrs by denaturing-PAGE analysis
Assay data:6 Tested
Inhibition of human recombinant Dicer-mediated pre-miR-29a processing assessed as reduction of mature miR-29a formation by Northern blot analysis (Rvb = 41%)
Inhibition of human recombinant Dicer-mediated pre-miR-29a without internal loop processing assessed as reduction of mature miR-29a formation by Northern blot analysis (Rvb = 30%)
Inhibition of human recombinant Dicer-mediated pre-miR-29a without bulge loop processing assessed as reduction of mature miR-29a formation by Northern blot analysis (Rvb = 51%)
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