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Inhibition of 70S ribosome-mediated protein synthesis in Escherichia coli at 5XMIC incubated for 1 hr by renilla luciferase based luminescence assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of 70S ribosome-mediated protein synthesis in Escherichia coli at 1XMIC incubated for 1 hr by renilla luciferase based luminescence assay
Binding affinity to Escherichia coli MRE600 70S ribosome assessed as inhibition constant preincubated for 90 mins followed by incubation with Rho-C12-PR-Spn for 90 mins by competitive fluorescence binding assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosomal subunit assessed as equilibrium dissociation constant by surface plasmon resonance analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosomal subunit assessed as dissociation constant by surface plasmon resonance analysis
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosomal subunit assessed as association rate constant by surface plasmon resonance analysis
Inhibition of Mycobacterium smegmatis wild type ribosomes assessed as inhibition of translation activity using Firefly luciferase mRNA reporter based luminescence analysis
Assay data:9 Active, 7 Activity ≤ 1 µM, 9 Tested
Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosome assessed as dissociation rate constant by SPR analysis
Assay data:9 Tested
Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosome assessed as dissociation constant by SPR analysis
Binding affinity to Staphylococcus aureus ATCC 43300 50S ribosome assessed as association constant by SPR analysis
Inhibition of ribosome-mediated translation in Cell-free Escherichia coli protein synthesis system using pCmGFP as plasmid incubated at 30 degreeC measured every 20 mins by invitro coupled transcription-translation system based fluorescence analysis
Assay data:4 Active, 1 Activity ≤ 1 µM, 21 Tested
Binding affinity to Staphylococcus aureus 70S ribosome assessed as reduction in BODIPY-Erythromycin A binding incubated for 1.5 hr by fluorescence polarization assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to Staphylococcus aureus 70S ribosome assessed as dissociation constant by measuring reduction in BODIPY-Erythromycin A binding incubated for 1.5 hr by fluorescence polarization assay
Antiribosomal activity against wild type bacterial ribosomes assessed as inhibition of luciferase production by cell-free translation assay
Assay data:2 Tested
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Inhibition of bacterial ribosome assessed as reduction in poly(U) synthesis
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Anti-ribosomal activity against bacterial 70S hybrid ribosomes assessed as inhibition of cell-free translation incubated for 35 mins by dual luciferase reporter assay
Assay data:3 Tested
Inhibition of 70S ribosome in Escherichia coli cell free system assessed as reduction in protein synthesis by measuring EmGFP synthesis at 1 uM by cell-free translation inhibition method relative to control
Binding affinity to Escherichia coli 70S ribosome assessed as reduction in BODIPY-Erythromycin A binding incubated for 1 hr by fluorescence polarization assay
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to Escherichia coli A19 70S ribosome after 30 mins by scintillation counting method
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