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Inhibition of human DNA polymerase gamma
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
DNA Polymerase Activity Assay from Article 10.1128/AAC.01311-05: "Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human DNA polymerase-gamma assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 100 uM by scintillation counting method relative to control
Assay data:8 Tested
Inhibition of human mitochondrial DNA polymerase gamma large subunit/DNA polymerase gamma accessory subunit using 32P-D19/D36 as DNA primer/template assessed as single nucleotide incorporation rate at 100 uM after 5 to 90 mins by PAGE analysis relative to thymidine NTP
Assay data:16 Tested
Inhibition of DNA polymerase-gamma (unknown origin) assessed as incorporation of Br(d)UTP by colorimetric analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human DNA polymerase gamma using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 mins
Inhibition of human DNA polymerase gamma at 100 uM
Assay data:2 Tested
Inhibition of human DNA polymerase gamma by microplate reader analysis
Assay data:4 Tested
Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding assay
Assay data:3 Tested
Inhibition of human recombinant DNA polymerase gamma by scintillation counting
Assay data:2 Active, 2 Tested
Ratio of polymerization constant K to Kd for human recombinant DNA polymerase gamma E200A mutant
Polymerizing activity of exonuclase deficient human recombinant DNA polymerase gamma E200A mutant assessed as rate of nucleotide incorporation by pre-steady state single nucleotide incorporation assay
Binding affinity to exonuclase deficient human recombinant DNA polymerase gamma E200A mutant
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human gamma polymerase
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