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Nicotinic Acetylcholine Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human AChE by Ellman's method
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Mixed type inhibition of AChE (unknown origin) assessed as inhibitory constant by Lineweaver-Burk plot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
NACH/H Eurofins SafetyScreen44 (BI)
Inhibition of human alpha1beta1deltaepsilon nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response at 10 uM by two-electrode voltage-clamp method relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human alpha1beta1deltaepsilon nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-electrode voltage-clamp method
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of adult human (alpha1)2beta1epsilondelta expressed in Xenopus laevis oocytes assessed as dissociation rate constant for inhibition of acetylcholine-induced channel current response at 1 nM at -70 mV holding potential by two-electrode voltage-clamp assay relative to control
Inhibition of rat alpha1beta1epsilondelta expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced channel current response at -70 mV holding potential by two-electrode voltage-clamp assay relative to control
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human erythrocyte AChE-induced amyloid beta 1 to 42 (unknown origin) aggregation up to 20 uM after 48 hrs by thioflavin T-based fluorometric assay relative to donepezil
Assay data:3 Tested
Drug metabolism assessed as mouse AChE-mediated hydrolysis by measuring 6-(1-(dimethylamino) ethyl) quinolin-8-ol incubated for 12 hrs by HPLC analysis
Drug metabolism assessed as mouse AChE-mediated hydrolysis by measuring 6-(1-(dimethylamino) ethyl) quinolin-8-ol incubated for 48 hrs by HPLC analysis
Potency index, ratio of rivastigmine IC50 to compound IC50 for AChE in rat brain cortex using acetylthiocholine iodide as substrate incubated for 15 mins by spectrophotometry
Inhibition of rat brain cortex AChE using acetylthiocholine iodide as substrate incubated for 15 mins by spectrophotometry
Assay data:4 Active, 15 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human recombinant AChE using acetylthiocholine iodide substrate by Ellman's protocol based assay
Assay data:16 Tested
Inhibition of AChE (unknown origin) relative to control
Assay data:6 Tested
Inhibition of AChE (unknown origin) by Ellman's method
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of AChE (unknown origin) by spectrophotometric analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of AChE from human erythrocytes
Assay data:2 Tested
Inhibition of human AChE using acetylthiocholine iodide as substrate after 10 secs measured at 30 s intervals for two minutes by Ellman's method
Assay data:1 Active, 7 Tested
Inhibition of human AChE at 100 uM using acetylthiocholine iodide as substrate after 10 secs measured at 30 s intervals for two minutes by Ellman's method relative to control
Assay data:4 Tested
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