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Inhibition of Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as depletion of total Lysosomal alpha-mannosidase activity using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Chaperone activity at human Lysosomal alpha-mannosidase R916C mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 20 uM incubated for 96 hrs relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Chaperone activity at human Lysosomal alpha-mannosidase R916C mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 2 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase R916C mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 0.2 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase L565P mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 20 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase L565P mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 2 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase L565P mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 0.2 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase L352P mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 20 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase L352P mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 2 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase L352P mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 0.2 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase H72L mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 20 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase H72L mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 2 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase H72L mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 0.2 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase C55F mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 20 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase C55F mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 2 uM incubated for 96 hrs relative to control
Chaperone activity at human Lysosomal alpha-mannosidase C55F mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 0.2 uM incubated for 96 hrs relative to control
Chaperone activity at Lysosomal alpha-mannosidase in human fibroblasts assessed as reduction in cholesterol accumulation at 0.2 uM incubated for 96 hrs by Amplex red cholesterol assay
Assay data:3 Tested
Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as reduction in cholesterol accumulation at 0.2 uM incubated for 96 hrs by Amplex red cholesterol assay relative to wild-type control
Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in total LAMAN at 0.2 uM incubated for 96 hrs by Western blot analysis
Assay data:2 Active, 2 Tested
Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts lysosome derived from alpha-Mannosidosis patient assessed as enzyme activity enhancement at 20 uM incubated for 96 hrs by sub-cellular fractionation analysis relative to control
Assay data:1 Tested
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