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GLO1 Activity Assay from Article 10.1038/nchembio.2326: "Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11."
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of glyoxylase-1 in human HL60 cells assessed as increase in methylglyoxal level in culture medium at 300 uM measured after 24 hrs by HPLC-UV analysis relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of glyoxylase-1 in human HL60 cells assessed as increase in methylglyoxal level in culture medium at 200 uM measured after 24 hrs by HPLC-UV analysis
Inhibition of glyoxylase-1 in human HL60 cells assessed as increase in methylglyoxal level in culture medium at 15 uM measured after 24 hrs by HPLC-UV analysis relative to control
Inhibition of glyoxylase-1 in human HL-60 cells assessed as reduction in MG accumulation in cell lysate
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of glyoxylase-1 in human HL60 cells assessed as increase in methylglyoxal level in culture medium at 200 uM measured after 24 hrs by HPLC-UV analysis relative to control
Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate by spectrophotometric method
Assay data:15 Active, 21 Tested
Inhibition of Glyoxalase-1 (unknown origin) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate at 100 uM by spectrophotometric method relative to control
Assay data:21 Tested
Inhibition of recombinant human N-terminal Met and 6-His-tagged Glyoxalase-1 (Ala2 to Met184 residues) using methylglyoxal and reduced glutathione as substrates by spectrophotometric method
Inhibition of recombinant human N-terminal Met and 6-His-tagged Glyoxalase-1 (Ala2 to Met184 residues) using glutathione and methylglyoxal as substrates preincubated for 15 mins followed by enzyme addition by double beam UV-vis spectrophotometric method
Assay data:10 Active, 25 Tested
Inhibition of recombinant human N-terminal Met and 6-His-tagged Glyoxalase-1 (Ala2 to Met184 residues) at 25 uM using glutathione and methylglyoxal as substrates preincubated for 15 mins followed by enzyme addition by double beam UV-vis spectrophotometric method relative to control
Assay data:25 Tested
Inhibition of human Glyoxalase-1 expressed in Escherichia coli BL21 (DE3)
Assay data:1 Active, 7 Tested
Inhibition of recombinant human Glyoxalase-1 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of S-D-lactoylglutathione formation using MG and reduced glutathione as substrate measured for 2 mins by spectrophotometric method
Assay data:3 Tested
Inhibition of human Glyoxalase-1 using GSH and MGO as substrate by Dixon plot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Glyoxalase-1 (unknown origin)
Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrate by Michaelis-Menten analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrate
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of human erythrocyte Glyoxalase-1
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of Glyoxalase-1 (unknown origin) using GSH and MGO as substrates preincubated with substrates for 6 mins followed by enzyme addition by spectrophotometric method
Inhibition of recombinant mouse Glyoxalase-1 expressed in Escherichia coli BL21 (DE3) pLysS cells using GSH and MGO as substrate by Dixon plot
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