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Selectivity interaction (KinomeScan (DiscoverX)) EUB0000549a TRPM6
Assay data:1 Tested
SummaryRelated BioAssays by Target
TRPM6 DiscoveRx kinase panel
ChaK1(h) Kinase panel
Inhibition of human CHAK1 at 1000 nM by KINOMEscan assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
KinomeScan assay: inhibition of TRPM6
Assay data:1 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
ChaK1(h) Eurofins kinase panel
ChaK1(h) Eurofins Kinase panel
ChaK1(h) Millipore kinase panel
Inhibition of human TRPM6 assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Inhibition of DNA-tagged human TRPM6 assessed as percent of control at 50000 nM by qPCR analysis relative to control
Inhibition of human TRPM6 assessed as percent of control at 1000 nM by KINOMEscan assay relative to control
Inhibition of recombinant human CHAK1 (1180 to end residues) assessed as residual activity at 10 uM using myelin basic protein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiometry assay relative to control
Inhibition of TRPM7 in NHLF assessed as inhibition of TGFB1-induced FMT by measuring alpha-SMA expression at 25 to 50 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Inhibition of TRPM7 in mouse NMuMG cells assessed as suppression of TGFbeta1-induced calpain activity by measuring Filamin-A levels at 25 to 50 uM incubated for 24 to 72 hrs by Western blot analysis
Assay data:2 Active, 2 Tested
Inhibition of TRPM7 in mouse NMuMG cells assessed as suppression of TGFbeta1-induced EMT by measuring alpha-SMA expression at 25 to 50 uM incubated for 24 to 72 hrs by Western blot analysis
Inhibition of recombinant human CHAK1 (1180 to end residues) at 1 uM using myelin ba as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting method relative to control
Inhibition of TRPM7 (unknown origin) at 1 uM relative to control
Binding affinity to wild-type human partial length TRPM6 (Q1723 to I1998 residues) expressed in mammalian expression system assessed as residual binding level at 10 uM by Kinomescan method relative to control
Inhibition of wild-type human partial length TRPM6 (Q1723 to I1998 residues) expressed in mammalian expression system at 1 uM by Kinomescan method relative to control
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