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Inhibition of MUC1 in human BT474 cells assessed as reduction in MUC1-C expression at 25 to 75 uM incubated for 3 days by immunoblot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of MUC1 in human MCF7 cells assessed as decrease in MUC1 protein level in whole cell lysates at 75 uM incubated for 3 days by immunoblot analysis
Assay data:1 Active, 2 Tested
Inhibition of MUC1 nuclear import in human MCF7 cells assessed as decrease in nuclear MUC1-C levels at 75 uM incubated for 3 days by immunoblot analysis
Inhibition of MUC1-CD dimerization in human MCF10A cells assessed as reduction in MUC1-C levels at 50 to 100 uM incubated for 3 days by immunoblot analysis
Inhibition of MUC1-CD dimerization (unknown origin) expressed in HEK293 cells assessed as disruption of interaction between Flag-MUC1-CD and GFP-MUC1-CD by coimmunoprecipitation assay
Inhibition of soluble unbound MUC1-CD dimerization (unknown origin) by immunoblot analysis
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of biotinylated MUC1-CD dimerization (unknown origin) assessed as decrease in oligomer formation by streptavidin-HRP based assay relative to control
Assay data:1 Tested
Inhibition of biotinylated MUC1-CD dimerization (unknown origin) assessed as decrease in oligomer formation at 100 uM by streptavidin-HRP based assay relative to control
Assay data:9 Tested
Inhibition of MUC1 nuclear import in human MCF7 cells assessed as decrease in nuclear MUC1-C levels at 5 uM by Western blot analysis
Inhibition of MUC1 nuclear import in human ZR-75-1 cells assessed as decrease in nuclear MUC1-C levels at 5 uM by Western blot analysis
Binding affinity to His-tagged MUC1-CD (unknown origin) immobilized BIAcore sensor chip
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of MUC1-CD dimerization (unknown origin) expressed in HEK293 cells assessed as disruption of interaction between Flag-MUC1-CD and GFP-MUC1-CD at 5 mM by coimmunoprecipitation assay
Inhibition of His-tagged MUC1-CD dimerization (unknown origin) assessed as decrease in oligomer formation incubated for 1 hr by SDS-polyacrylamide electrophoresis method based luminescence assay
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