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Inhibition of USP30 (unknown origin) using ubiquitin rhodamine 110 as substrate at 1 to 10 uM by DUBprofiler fluorometric assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human USP30 using ubiquitin rhodamine 110 as substrate at 10 to 50 uM by fluorometric assay
Assay data:1 Tested
Inhibition of human USP30 (57 to 517 residues) expressed in Sf9 cells using ubiquitin rhodamine 110 as substrate assessed as remaining enzyme activity at 10 to 50 uM by fluorometric assay
Inhibition of USP30 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In Vitro USP30 Biochemical Assay from US Patent US11845724: "USP30 inhibitors and uses thereof"
Assay data:120 Active, 99 Activity ≤ 1 µM, 140 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Ubiquitin-Rhodamine 110 Assay for USP30 Activity from US Patent US11814386: "Fused pyrrolines which act as ubiquitin-specific protease 30 (USP30) inhibitors"
Assay data:19 Active, 22 Activity ≤ 1 µM, 22 Tested
USP30 Biochemical IC50 Assay from US Patent US20230312580: "1-(5-(2-CYANOPYRIDIN-4-YL)OXAZOLE-2-CARBONYL)-4-METHYLHEXAHYDROPYRROLO[3,4-B]PYR ROLE-5(1H)-CARBONITRILE AS USP30 INHIBITOR FOR USE IN THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION, CANCER AND FIBROSIS"
Assay data:8 Active, 6 Activity ≤ 1 µM, 9 Tested
USP30 Biochemical IC50 Assay from US Patent US20230303547: "N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS"
Assay data:12 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 12 Tested
USP30 Enzymatic Assay (Rhodamine Assay) from US Patent US11572374: "N-cyano-7-azanorbornane derivatives and uses thereof"
Assay data:408 Active, 255 Activity ≤ 1 µM, 452 Tested
Inhibition of GST-tagged recombinant USP30 (unknown origin) using Ub-Lys-TAMRA as substrate at 1 uM incubated for 30 mins by fluorescence polarization assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
USP30 Biochemical IC50 Assay from US Patent US11414402: "Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors"
Assay data:32 Active, 26 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
USP30 Biochemical Fluorescence Intensity IC50 Assay from US Patent US11390584: "1-cyano-pyrrolidine compounds as USP30 inhibitors"
Assay data:266 Active, 244 Activity ≤ 1 µM, 267 Tested
USP30 Biochemical IC50 Assay from US Patent US11370784: "Cyano-substituted heterocycles with activity as inhibitors of USP30"
Assay data:77 Active, 43 Activity ≤ 1 µM, 92 Tested
Biochemical IC50 Assay from US Patent US11352339: "1-cyano-pyrrolidine derivatives as DUB inhibitors"
Assay data:196 Active, 129 Activity ≤ 1 µM, 198 Tested
UCHL1 Biochemical IC50 Assay from US Patent US11319287: "Cyanopyrrolidines as dub inhibitors for the treatment of cancer"
Assay data:78 Active, 32 Activity ≤ 1 µM, 85 Tested
Biochemical Assay from US Patent US11130748: "Compounds"
Assay data:77 Active, 48 Activity ≤ 1 µM, 78 Tested
USP30 Biochemical Fluorescence Intensity IC50 Assay from US Patent US11053198: "1-cyano-pyrrolidine compounds as USP30 inhibitors"
Assay data:115 Active, 104 Activity ≤ 1 µM, 116 Tested
Biochemical Assay from US Patent US11091488: "1-cyano-pyrrolidine derivatives as inhibitors of USP30"
Assay data:78 Active, 78 Activity ≤ 1 nM, 78 Activity ≤ 1 µM, 78 Tested
Biochemical Assay from US Patent US11084821: "Cyanopyrrolidine derivatives with activity as inhibitors of USP30"
Assay data:26 Active, 20 Activity ≤ 1 µM, 27 Tested
USP30 Biochemical IC50 Assay from US Patent US11059809: "Substituted cyanopyrrolidines with activity as DUB inhibitors"
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
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