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Inhibition of Hepatitis C virus NS5B polymerase
Assay data:2 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
HCV NS5B Pol assay ([32P]-UTP) from US Patent US11857560: "Pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections"
Assay data:9 Active, 3 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
HCV NS5B Pol assay ([32P]-CTP]) from US Patent US11857560: "Pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections"
Assay data:7 Active, 1 Activity ≤ 1 µM, 11 Tested
Inhibition of deltaC55 truncated Hepatitis C virus NS5B expressed in Escherichia coli using poly(rA)/oligo(rU) as template/primer incubated for 20 mins in presence of 3H-UTP by radioactivity based assay
Assay data:1 Active, 1 Tested
Inhibition of Hepatitis C virus NS5B RNA-dependent-RNA-polymerase
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Rhinovirus Polymerase (HRV1bpol) and HCV Polymerase (HCVpol) Assays from US Patent US11149049: "Substituted nucleosides, nucleotides and analogs thereof"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Measuring Compound Inhibitory Potency from US Patent US11053243: "Inhibitors of hepatitis C virus replication"
Assay data:50 Active, 39 Activity ≤ 1 nM, 50 Activity ≤ 1 µM, 50 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US10793591: "Substituted nucleosides, nucleotides and analogs thereof"
Assay data:15 Active, 14 Activity ≤ 1 µM, 15 Tested
HCV Polymerase Enzyme Assay from US Patent US10513534: "2′-chloro nucleoside analogs for HCV infection"
Assay data:10 Active, 2 Activity ≤ 1 µM, 11 Tested
Inhibition Assay from US Patent US9457039: "2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases"
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
Cell-Based HCV Replicon Assay from US Patent US9457039: "2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases"
Assay data:1 Active, 15 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
NS5B RNA Polymerase Assay from US Patent US9447132: "Highly active nucleoside derivative for the treatment of HCV"
Assay data:2 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Transient Transfection Assay from US Patent US9433609: "Benzimidazole-imidazole derivatives"
Assay data:20 Active, 18 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
Stable Transfection Assay from US Patent US9433609: "Benzimidazole-imidazole derivatives"
Immumoenzymatic Assay from US Patent US9428491: "Substituted azoles, antiviral active component, pharmaceutical composition, method for preparation and use thereof"
Assay data:10 Active, 10 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Reporter Assay from US Patent US9428469: "Antiviral compounds"
Assay data:17 Active, 6 Activity ≤ 1 µM, 29 Tested
Surface Plasmon Resonance (SPR)-Based Assay from US Patent US9427440: "Macrocyclic indole derivatives useful as hepatitis C virus inhibitors"
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
Primer-Dependent Transcription Assay from US Patent US9427440: "Macrocyclic indole derivatives useful as hepatitis C virus inhibitors"
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
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