Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19638091.

hERG Qpatch Assay Protocol from US Patent US20240199576: "NOVEL CYCLOPENTA[C]PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B"

Source:: BindingDB

Protein Targets:: Potassium voltage-gated channel subfamily H member 2; ...
Total:: 1

Assay data:3 Active, 5 Tested

AID:: 1963809

Summary Compounds, Active Related BioAssays by Target

Select item 19637862.

[3H]DA and [3H]5-HT Uptake Assay from US Patent US11999676: "Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse"

Source:: BindingDB

Protein Targets:: Potassium voltage-gated channel subfamily H member 2; ...
Total:: 2

Assay data:90 Active, 90 Activity ≤ 1 µM, 91 Tested

AID:: 1963786

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19637063.

hERG Channel Inhibitory Activity Assay from US Patent US20240150370: "BICYCLIC PYRIDINE DERIVATIVE"

Source:: BindingDB

Protein Targets:: Potassium voltage-gated channel subfamily H member 2; ...
Total:: 1

Assay data:2 Active, 39 Tested

AID:: 1963706

Summary Compounds, Active Related BioAssays by Target

Select item 19636124.

hERG Assay from US Patent US11970463: "Compounds and their use"

Source:: BindingDB

Protein Targets:: Potassium voltage-gated channel subfamily H member 2; ...
Total:: 1

Assay data:1 Active, 35 Tested

AID:: 1963612

Summary Compounds, Active Related BioAssays by Target

Select item 19634655.

hERG Channel Activity from US Patent US11912693: "Compounds for modulating S1P1 activity and methods of using the same"

Source:: BindingDB

Protein Targets:: Potassium voltage-gated channel subfamily H member 2; ...
Total:: 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 11 Tested

AID:: 1963465

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19634556.

Experimental Evaluation of the In Vitro Inhibitory Effect (IC50) of hERG from US Patent US11912663: "Multi-targeted tyrosine kinase inhibitors and their pharmaceutical uses"

Source:: BindingDB

Protein Targets:: Potassium voltage-gated channel subfamily H member 2; ...
Total:: 1

Assay data:15 Tested

AID:: 1963455

Summary Related BioAssays by Depositor Related BioAssays by Target

Select item 19631517.

Cross screening panel

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1963151

Summary Related BioAssays by Target

Select item 19630618.

Safety47 Scan (DiscoverX - Eurofins)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1963061

Summary Related BioAssays by Target

Select item 19625699.

Potassium Channel hERG Eurofins Panlabs panel

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1962569

Summary Related BioAssays by Target

Select item 196238410.

HERG_DOFETILIDE Eurofins SafetyScreen44 (BI)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1962384

Summary Related BioAssays by Target

Select item 196233511.

HERG_DOFETILIDE Eurofins SafetyScreen44 (BI)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1962335

Summary Related BioAssays by Target

Select item 196223612.

HERG_DOFETILIDE Eurofins SafetyScreen44 (BI)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1962236

Summary Related BioAssays by Target

Select item 196219013.

HERG_DOFETILIDE Eurofins SafetyScreen44 (BI)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1962190

Summary Related BioAssays by Target

Select item 196212514.

HERG_DOFETILIDE Eurofins SafetyScreen44 (BI)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1962125

Summary Related BioAssays by Target

Select item 196209415.

HERG_DOFETILIDE Eurofins SafetyScreen44 (BI)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1962094

Summary Related BioAssays by Target

Select item 196205016.

HERG_DOFETILIDE Eurofins SafetyScreen44 (BI)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1962050

Summary Related BioAssays by Target

Select item 196178517.

Compound was evaluated for inhibition of human KCNH2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:353 Active, 116 Activity ≤ 1 µM, 1804 Tested

AID:: 1961785

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196157118.

Inhibition of human ERG

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Active, 1 Tested

AID:: 1961571

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 196126719.

Inhibition of hERG

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1961267

Summary PubMed Citation Related BioAssays by Target

Select item 196070220.

Binding affinity to hERG (unknown origin)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:1 Tested

AID:: 1960702

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (34)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (1,626)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (27)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (739)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (2,602)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (8)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (29)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (4,111)
BioAssays extracted from the literature
NIH MLP (30)
BioAssays deposited by the NIH Molecular Libraries Program
Other (69)
BioAssays deposited by other experimentalists

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