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Compound was evaluated for inhibition of human ABCB11 in an in vitro assay with cellular components measured by filtration, liquid scintillation counting
Assay data:43 Active, 3 Activity ≤ 1 µM, 508 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of BSEP (unknown origin) upto 10000 nM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of BSEP (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of BSEP (unknown origin) at >30 uM
Assay data:2 Active, 6 Tested
HMT Assay from Article 10.1038/nchembio.2304: "An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition Assay from US Patent US9090657: "Compound and methods for its production"
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:2 Tested
Inhibition of human BSEP upto 10 uM using taurocholate as substrate preincubated for 15 mins followed by Mg-ATP or AMP addition and measured after 5 mins by microplate scintillation counter analysis
Inhibition of human BSEP assessed as reduction in BSEP-mediated taurocholate transport at 345 uM relative to control
Inhibition of human BSEP expressed in baculovirus infected Hi5 insect cells in presence of taurocholic acid by LC-MS/MS analysis
Inhibition of human BSEP expressed in HEK293 cell membrane vesicles assessed as reduction in 3H-TCA uptake incubated for 5 mins by radiodetection method
Assay data:15 Active, 2 Activity ≤ 1 µM, 15 Tested
Inhibition of human BSEP in plasma membrane vesicles after 10 mins in presence of [3H]-taurocholate by topcount based transport assay
Inhibition of recombinant human BSEP expressed in baculovirus infected Sf21 insect cell vesicles assessed as reduction in NBD-taurocholate uptake by fluorescence assay
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