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Inhibition of KEAP1/p62 (unknown origin) protein-protein interaction
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to N-terminal P62 LB domain (unknown origin) expressed in HEK293T cells
Binding affinity to N-terminal P62 (1 to 335 residues) in human HCT-116 cells lysates
Binding affinity to P62 (unknown origin) by MST assay
Binding affinity to P62 in human HCT-116 cells lysates at 10 uM incubated for 12 hrs by pull-down based immunoblot assay
Assay data:1 Active, 2 Tested
Inhibition of Sequestosome-1 in mouse C2C12 cells assessed as reduction in phospho-sites occupancy at 4 uM after 5 hrs by SILAC based LC-MS/MS analysis relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to SQSTM1 in human K562 cells at 1 mM incubated for 2 hrs by LC-MS/MS analysis based pull down assay relative to control
Binding affinity to SQSTM1 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Inhibition of recombinant GST-His-tagged Keap1-DC domain (321 to 609 residues) (unknown origin) expressed in Escherichia coli/FAM-labeled phosphorylated p62 (unknown origin) interaction measured after 30 mins by fluorescence polarization assay
Assay data:10 Active, 7 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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