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Inhibitory Assay from US Patent US20240116873: "QUINOLINE MERCAPTOACETATE SULFONAMIDE DERIVATIVE, INTERMEDIATE, PHARMACEUTICAL DERIVATIVE OR FORMULATION, AND PREPARATION METHOD AND USE THEREFOR"
Assay data:8 Active, 3 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Substrate activity at OAT1 (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of OAT1 (unknown origin)
Inhibition of OAT1 (unknown origin) expressed in HEK293 cells assessed as inhibition of 6-CFL uptake preincubated for 30 mins followed by incubation with 6-CFL and measured after 15 mins by fluorescence based analysis
Assay data:4 Tested
Inhibition of OAT3 (unknown origin) expressed in HEK293 cells
Inhibition of OAT1 (unknown origin) expressed in HEK293 cells
Inhibition of human OAT1 assessed as reduction in intracellular probe substrate accumulation upto 100 uM by microplate scintillation counter analysis relative to control
Inhibition of human OAT1 assessed as reduction in OAT1-mediated tenofovir transport
Inhibition of human OAT1 assessed as reduction in OAT1-mediated tenofovir transport at 14900 uM relative to control
Inhibition of OAT1 (unknown origin) at upto 3 uM
Inhibition of OAT1 (unknown origin) at 1 to 10 uM
Inhibition of human SLC22A6 expressed in HEK293 cells in presence of para-aminohippuric acid/metformin
Inhibition of human OAT1
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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