Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19596441.

Inhibition of ALK L1196M mutant (unknown origin) using biotin-TK peptide as substrate in presence of ATP incubated for 90 mins by HTRF assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1959644

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19596432.

Inhibition of ALK C1156Y mutant (unknown origin) using biotin-TK peptide as substrate in presence of ATP incubated for 90 mins by HTRF assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1959643

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19596423.

Inhibition of wild type ALK (unknown origin) using biotin-TK peptide as substrate in presence of ATP incubated for 90 mins by HTRF assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1959642

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19591644.

Inhibition of ALK (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay relative to control

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Tested

AID:: 1959164

Summary PubMed Citation Related BioAssays by Target

Select item 19564645.

Inhibition of human ALK at 200 nM by Z'-lyte assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Tested

AID:: 1956464

Summary PubMed Citation Related BioAssays by Target

Select item 19559056.

Inhibition of ALK (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Tested

AID:: 1955905

Summary PubMed Citation Related BioAssays by Target

Select item 19559007.

Inhibition of ALK G1202R mutant (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested

AID:: 1955900

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19558998.

Inhibition of wild type ALK (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested

AID:: 1955899

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19556829.

Inhibition of ALK (unknown origin) pre-incubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by mobility shifting assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1955682

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194110610.

Inhibition of ALK L1196M mutant (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1941106

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194110511.

Inhibition of ALK (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1941105

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194088612.

Binding affinity to human recombinant ALK L1196M mutant (1093 to 1411 residues) assessed as inhibition constant using 5'FAM-KKSRGDYMTMQIG-CONH2 peptide as substrate in presence of ATP by micro-fluidic mobility shift assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1940886

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193493213.

Inhibition of ALK G1202R mutant (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1934932

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193493114.

Inhibition of ALK L1196M mutant (unknown origin)

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1934931

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193484015.

Inhibition of human partial length ALK (I1088/E1409) expressed in mammalian system at 1 uM by KINOMEscan analysis relative to control

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Tested

AID:: 1934840

Summary PubMed Citation Related BioAssays by Target

Select item 193466716.

Inhibition of N-terminal GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) L1196M mutant expressed in baculovirus-infected Sf21 cells using LANCE Ultra ULight-PolyGT substrate incubated for 2 hrs by TR-FRET assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested

AID:: 1934667

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193466617.

Inhibition of N-terminal GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) C1156Y mutant expressed in baculovirus-infected Sf21 cells using LANCE Ultra ULight-PolyGT substrate incubated for 2 hrs by TR-FRET assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested

AID:: 1934666

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193466518.

Inhibition of N-terminal GST-tagged human wild type ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus-infected Sf21 cells using LANCE Ultra ULight-PolyGT substrate incubated for 2 hrs by TR-FRET assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested

AID:: 1934665

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193466419.

Inhibition of N-terminal GST-tagged human wild type ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus-infected Sf21 cells using LANCE Ultra ULight-PolyGT substrate at 100 nM incubated for 2 hrs by TR-FRET assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:8 Tested

AID:: 1934664

Summary PubMed Citation Related BioAssays by Target

Select item 192403820.

Inhibition of ALK (unknown origin) by radiometric ATP-competitive kinase assay

Source:: ChEMBL

Protein Target:: ALK tyrosine kinase receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1924038

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (4)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (634)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (95)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (461)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (546)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (1,184)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
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BioAssays deposited by other experimentalists

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