Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Biological Assay from US Patent US20240083896: "Nitrogen Containing 2,3-Dihydroquinazolinone Compounds as Nav1.8 Inhibitors"
Assay data:22 Active, 15 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
E-VIPR Assay Detecting and Measuring Nav Inhibition Properties from US Patent US11919887: "Substituted tetrahydrofurans as modulators of sodium channels"
Assay data:54 Active, 107 Activity ≤ 1 µM, 107 Tested
Cross screening panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Safety47 Scan (DiscoverX - Eurofins)
Sodium Channel, Site 2 Eurofins Panlabs panel
NA+/SITE2/R Eurofins SafetyScreen44 (BI)
Compound was evaluated for inhibition of human SCN5A in an in vitro cell-based assay measured by IonWorks automated patch clamp
Assay data:37 Active, 5 Activity ≤ 1 µM, 230 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Nav1.7 (unknown origin)
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Nav1.5 channel (unknown origin) upto 10000 nM
Inhibition of human Nav1.6 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated voltage clamp electrophysiology technique
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human Nav1.1 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -40 mV holding potential by PatchXpress automated voltage clamp electrophysiology technique
Inhibition of human Nav1.2 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -35 mV holding potential by PatchXpress automated voltage clamp electrophysiology technique
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on