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TBD from US Patent US11530198: "Compositions and methods for treating infections"
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of recombinant Leishmania major DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis
Assay data:24 Active, 15 Activity ≤ 1 µM, 34 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant Trypanosoma brucei DHFR-TS expressed in Escherichia coli BL21 (DE3) cells using dihydrofolate as substrate in presence of NADPH by spectrophotometric analysis
Assay data:22 Active, 12 Activity ≤ 1 µM, 34 Tested
Inhibition of Trypanosoma cruzi DHFR-TS in presence of NADPH by spectrophotometry
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant Trypanosoma cruzi DHFR-TS assessed as inhibition constant
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Trypanosoma cruzi DHFR-TS assessed as inhibition constant using DHF as substrate in presence of NADPH by spectrophotometry
Inhibition Assay from Article 10.1016/j.chembiol.2003.11.012: "Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase."
Assay data:7 Active, 4 Activity ≤ 1 µM, 7 Tested
Inhibition of Leishmania major DHFR
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of Leishmania major DHFR assessed by NADPH oxidation measured by spectrophotometric method
Assay data:2 Active, 1 Activity ≤ 1 µM, 5 Tested
Inhibition of Leishmania major DHFR in promastigote stage Leishmania major using dihydrofolic acid as substrate in presence of NADPH measured after 5 days by spectrophotometric method
Assay data:12 Active, 10 Activity ≤ 1 µM, 14 Tested
Binding affinity to Leishmania major DHFR
Assay data:4 Active, 2 Activity ≤ 1 µM, 6 Tested
Inhibition of Leishmania major DHFR at 1 mM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Leishmania major DHFR at 25 uM
Inhibition of Leishmania major DHFR at 50 uM
Assay data:7 Tested
Inhibition of Leishmania major DHFR at 500 uM
Assay data:4 Tested
Assay data:5 Tested
Activity of Trypanosoma cruzi DHFR by Lineweaver-Burke plot
Inhibition of Trypanosoma cruzi DHFR by Lineweaver-Burke plot
Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
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