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TLK1 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000586a TLK1
Thermal Shift Assay. Domain: start/stop: D448-N746
Assay data:27 Tested
Inhibition of TLK2 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of TLK1 (unknown origin)
Inhibition of human full length recombinant TLK1 assessed as residual activity at 1 uM using casein as substrate incubated for 40 mins in presence of [gamma 33P]-ATP by radiometric scintillation counting assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of full length GFP-tagged TLK1 (unknown origin) transfected in HEK293T cells at 50 uM using GST-ASF1a as substrate incubated for 30 mins by Western blot analysis
Binding affinity to full length FLAG/HA/Strep-tagged TLK2 (388 to 772 residues) (unknown origin) transfected in HEK293T cells by Alexa Fluor 647 staining based FRET assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) transfected in HEK293T cells assessed as reduction in ASF1a phosphorylation at S166 residue at 5 uM by Western blot analysis
Assay data:5 Active, 5 Tested
Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) in human MDA-MB-231 cells assessed as reduction in ASF1 phosphorylation at 16.7 uM measured after 4 hrs by Western blot analysis
Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) in human U2OS cells assessed as ASF1 phosphorylation by measuring decrease in band shift at 16.7 uM measured after 4 hrs by Western blot analysis
Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) in human U2OS cells assessed as reduction in ASF1 phosphorylation at 16.7 uM measured after 4 hrs by Western blot analysis
Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) transfected in HEK293T cells assessed as reduction in TLK mediated ASF1a phosphorylation at 50 uM by Western blot analysis
Assay data:1 Active, 2 Tested
Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) transfected in HEK293T cells at 50 uM using GST-ASF1 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins in presence of ATP by Western blot analysis
Assay data:3 Active, 3 Tested
TLK2 DiscoveRx kinase panel
TLK1 DiscoveRx kinase panel
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