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PCTK1 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of CDK (unknown origin)
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CDK16 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assay
Assay data:2 Tested
Inhibition of CDK14 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assay
Inhibition of CDK16 (unknown origin) by Kinomescan method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CDK14 (unknown origin) by Kinomescan method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Thermal Shift Assay. Domain: start/stop: E163-S478
Assay data:27 Tested
Inhibition of CDK14/cyclinY (unknown origin) at 10 uM relative to control
Inhibition of His6-tagged full length human recombinant CDK16 expressed in Sf9 insect cells at 1 uM incubated for 60 mins in presence of [gamma33P]ATP by microplate scintillation counter relative to control
Inhibition of CDK14 (unknown origin) incubated for 6 hrs by NanoBRET assay
Inhibition of GST-tagged human recombinant full-length CDK14 (2 to end residues) expressed in baculovirus expression system preincubated for 30 mins by Lanthascreen Eu-Kinase binding assay
Inhibition of human CDK16 at 0.5 uM assessed as competition rate relative to control
Inhibition of human CDK16/cyclin-Y protein-protein complex
Inhibition of human CDK16/cyclin-Y at 0.5 uM relative to control
Inhibition of PCTAIRE1 (unknown origin) at 1 uM by kinase-profiling analysis
Induction of CDK16 degradation in human 22Rv1 cells at 3 uM measured after 36 hrs by DIA-based proteomics analysis
PCTK1 DiscoveRx kinase panel
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