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Binding Assay from US Patent US11285226: "Aryl ethene derivative and pharmaceutical composition containing same as active ingredient"
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding Assay from US Patent US10934303: "Aryl ethene derivative and pharmaceutical composition containing same as active ingredient"
Assay data:28 Active, 13 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:28 Active, 28 Activity ≤ 1 µM, 28 Tested
Radioligand Displacement Assay from Article 10.1016/j.bbrc.2008.06.050: "ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner."
Assay data:3 Active, 3 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
ERRgamma FRET Assay from Article 10.1021/jm050161j: "Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma."
Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested
Radioligand Displacement Assay from Article 10.1016/j.bmcl.2005.11.030: "Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma."
Assay data:11 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Competitive Radioligand-Binding Assay from US Patent US9604931: "Nuclear receptor binding agents"
Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Modulation of ERRgamma (unknown origin) expressed in MG63 cells assessed as transcriptional activity up to 7.9 uM incubated for 18 hrs by dual-Glo luciferase assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Modulation of ERRbeta (unknown origin) expressed in MG63 cells assessed as transcriptional activity up to 7.9 uM incubated for 18 hrs by dual-Glo luciferase assay relative to control
Inverse agonist activity at ERRgamma in human BHP10-3SCp cells assessed as increase in [131-I] uptake at 12 uM in presence of NIS-specific inhibitor, KClO4
Inverse agonist activity at ERRgamma in human BHP10-3SCp cells assessed as increase in [131-I] uptake
Inverse agonist activity at ERRgamma in human BCPAP cells assessed as increase in p42 MAPK phosphorylation at 6 to 12 uM by immunoblot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inverse agonist activity at ERRgamma in human BCPAP cells assessed as increase in p44 MAPK phosphorylation at 6 to 12 uM by immunoblot analysis
Inverse agonist activity at ERRgamma in human CAL-62 cells assessed as increase in p44 MAPK phosphorylation at 6 to 12 uM by immunoblot analysis
Inverse agonist activity at ERRgamma in human BHT-101 cells assessed as increase in p44 MAPK phosphorylation at 6 to 12 uM by immunoblot analysis
Inverse agonist activity at ERRgamma in human BHP10-3SCp cells assessed as increase in p44 MAPK phosphorylation at 6 to 12 uM by immunoblot analysis
Inverse agonist activity at ERRgamma in human CAL-62 cells assessed as increase in membrane glycosylated NIS protein level at 12 uM by immunoblot analysis
Inverse agonist activity at ERRgamma in human BHT-101 cells assessed as increase in membrane glycosylated NIS protein level at 12 uM by immunoblot analysis
Inverse agonist activity at ERRgamma in human BCPAP cells assessed as increase in membrane glycosylated NIS protein level at 12 uM by immunoblot analysis
Inverse agonist activity at ERRgamma in human BHP10-3SCp cells assessed as increase in membrane glycosylated NIS protein level at 12 uM by immunoblot analysis
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