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assay on hold
Summary
GTP-KRAS and cRAF Interaction Assay from US Patent US20240199644: "Fused Ring Derivatives Useful as KRAS G12D Inhibitors"
Assay data:16 Active, 4 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding Assay from US Patent US20240199635: "TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS"
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Homogeneous Time-Resolved Fluorescence (HTRF) from US Patent US20240199625: "BICYCLIC HETEROCYCLIC FGFR4 INHIBITOR, PHARMACEUTICAL COMPOSITION AND PREPARATION COMPRISING SAME, AND APPLICATION THEREOF"
Assay data:8 Active, 3 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Surface Plasmon Resonance Assay from US Patent US20240197735: "METHODS AND COMPOSITIONS COMPRISING A BRAF INHIBITOR AND A PD-1 BINDING ANTAGONIST"
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Biochemical Assay from US Patent US20240182487: "MACROCYCLES AND THEIR USE"
Assay data:40 Active, 3 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 42 Tested
Biological Assay from US Patent US20240182466: "A Crystal Form of a Fluorine-substituted Pyridopyrazole Compound and a Preparation Method Thereof"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Measurement of FXIa Inhibition from US Patent US20240174633: "CRYSTALLINE FORMS OF (4S)-24-CHLORO-4-ETHYL-73-FLUORO-35-METHOXY-32,5-DIOXO-14-(TRIFLUORO-METHYL)-32H-6-AZA-3(4,1)-PYRIDINA-1(1)-[1,2,3]TRIAZOLA-2(1,2),7(1)-DIBENZENAHEPTAPHANE-74-CARBOXAMIDE"
Kinase Assay from US Patent US20240174621: "METHYLQUINAZOLINONE DERIVATIVES"
Assay data:5 Active, 3 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition Tests on JAK-1, JAK-2 and JAK-3 Kinases from US Patent US11993603: "Preparation for 6-amino-1H-pyrazolo[3,4-d]pyrimidine-based JAK kinase inhibitor and application thereof"
Assay data:28 Active, 11 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
HTRF-Based EGFR Biochemical Assay from US Patent US20240166665: "COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF"
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
JAK2 Activity Inhibitory Assay from US Patent US20240150367: "NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USE THEREOF"
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) from US Patent US20240150366: "4-AMINOQUINAZOLINE COMPOUND"
Assay data:21 Active, 21 Activity ≤ 1 µM, 21 Tested
Inhibitory Activity Assay from US Patent US11976059: "Isoindolin-1-on derivative, method for preparing same, and pharmaceutical composition comprising same as effective component for preventing or treating cancer"
Assay data:63 Active, 47 Activity ≤ 1 µM, 71 Tested
BRAF-Inhibiting Assay from US Patent US11964950: "Arylamide derivative having antitumor activity"
Assay data:175 Active, 5 Activity ≤ 1 nM, 174 Activity ≤ 1 µM, 175 Tested
HCK Kinase Assay from US Patent US11963960: "Compounds for treating or inhibiting recurrence of acute myeloid leukemia"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
JAK2 Binding Assay from US Patent US20240116892: "HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS"
Assay data:263 Active, 254 Activity ≤ 1 µM, 264 Tested
Radiometric Assay from US Patent US20240140952: "INHIBITORS AND DEGRADERS OF JANUS KINASE 2"
Assay data:15 Active, 9 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Kinetic Labeling Experiments of Ibrutinib Derivatives with BTK from US Patent US20240139326: "METHACRYLAMIDES PROTEIN BINDERS AND USES THEREOF"
Assay data:10 Active, 8 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Biochemical Kinase Assay Protocol (JAK) from US Patent US20240132525: "BORON CONTAINING PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF"
Assay data:90 Active, 39 Activity ≤ 1 nM, 91 Activity ≤ 1 µM, 91 Tested
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