Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19624131.

IKBKB Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1962413

Summary Related BioAssays by Target

Select item 19622662.

IKBKB Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1962266

Summary Related BioAssays by Target

Select item 19490263.

Inhibition of IKK2 (unknown origin) by Ambit kinase assay

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:3 Tested

AID:: 1949026

Summary PubMed Citation Related BioAssays by Target

Select item 19451844.

Inhibition of IkappaB phosphorylation in LPS-induced mouse RAW264.7 cells preincubated with compound for 2 hrs followed by LPS stimulation and measured after 6 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1945184

Summary PubMed Citation Related BioAssays by Target

Select item 19408685.

Inhibition of IKKB (unknown origin)

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:2 Activity ≤ 1 µM, 2 Tested

AID:: 1940868

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19348536.

Inhibition of human full length wild type IKKalpha expressed in mammalian system at 1 uM by KINOMEscan analysis relative to control

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Assay data:1 Tested

AID:: 1934853

Summary PubMed Citation Related BioAssays by Target

Select item 19198057.

Kinase (PDGFRα, PDGFRβ, ABL1 and FLT3) Inhibition Test of Compounds from US Patent US20230312529: "PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF"

Source:: BindingDB

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 6

Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested

AID:: 1919805

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19195358.

In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"

Source:: BindingDB

Protein Targets:: Inhibitor of nuclear factor kappa-B kinase subunit beta; ...
Total:: 16

Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested

AID:: 1919535

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19155499.

Inhibition of IKKa (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Assay data:1 Tested

AID:: 1915549

Summary PubMed Citation Related BioAssays by Target

Select item 191543510.

Selectivity interaction (Kinase Panel (competition binding assay)) EUB0000589aTFA IKBKB

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915435

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191465211.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000750a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1914652

Summary Related BioAssays by Target

Select item 191464012.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000749a CHUK

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Assay data:1 Tested

AID:: 1914640

Summary Related BioAssays by Target

Select item 191393113.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000701a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1913931

Summary Related BioAssays by Target

Select item 191350014.

Selectivity interaction (Enzymatic assay) EUB0000624a IKBKB

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1913500

Summary Related BioAssays by Target

Select item 191349915.

Selectivity interaction (Enzymatic assay) EUB0000624a CHUK

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Assay data:1 Tested

AID:: 1913499

Summary Related BioAssays by Target

Select item 191345716.

Selectivity interaction (Kinase panel (enzymatic assay)) EUB0000153b CHUK

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Assay data:1 Tested

AID:: 1913457

Summary Related BioAssays by Target

Select item 191336717.

Affinity Biochemical interaction (Competition binding assay) EUB0000589aTFA IKBKB

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913367

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191316318.

Affinity Biochemical interaction (TR-FRET-based kinase activity inhibition assay (1 M ATP)) EUB0000701a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Active, 1 Tested

AID:: 1913163

Summary Compounds, Active Related BioAssays by Target

Select item 191315819.

Affinity Biochemical interaction (TR-FRET-based kinase activity inhibition assay (1 M ATP)) EUB0000305b IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913158

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191290520.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000701a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1912905

Summary Related BioAssays by Target

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Target

Proteins (7)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (358)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (17)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (211)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (404)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (1,197)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (112)
BioAssays deposited by other experimentalists

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PubChem BioAssay
Chromosome neighbors for GEO Profiles (Select 30550694) (20)
GEO Profiles
Related DataSets for GEO Profiles (Select 30555163) (1)
GEO DataSets
Triterpenoid celastrol treatment and heat shock comparison
Triterpenoid celastrol treatment and heat shock comparison
Accession: GDS2343

GEO DataSets
PMC Links for Nucleotide (Select 71658757) (1)
PMC

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