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Inhibition Tests on JAK-1, JAK-2 and JAK-3 Kinases from US Patent US11993603: "Preparation for 6-amino-1H-pyrazolo[3,4-d]pyrimidine-based JAK kinase inhibitor and application thereof"
Assay data:28 Active, 11 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
JAK3 Activity Inhibitory Assay from US Patent US20240150367: "NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USE THEREOF"
Assay data:67 Active, 66 Activity ≤ 1 µM, 67 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Biochemical JAK Kinase Assays from US Patent US20240092758: "IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS"
Assay data:392 Active, 381 Activity ≤ 1 nM, 392 Activity ≤ 1 µM, 392 Tested
In Vitro Test of Activities of Jak1, Jak2, Jak3, Tyk2 Kinases from US Patent US11919896: "[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof"
Assay data:14 Active, 1 Activity ≤ 1 µM, 34 Tested
TBD from US Patent US20240059694: "COMPOUND CONTAINING 1,3-BENZODIOXOL STRUCTURE AND PREPARATION METHOD AND USE THEREOF"
Assay data:28 Active, 30 Activity ≤ 1 µM, 30 Tested
PRKCA Invitrogen Lab (UK) kinase screen (BI)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of PKCa (unknown origin) at 10 uM by biochemical hotspot kinase assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of JAK3 (unknown origin) at 10 uM by biochemical hotspot kinase assay
Inhibition of PKCB (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PKC (unknown origin) using acetylated myelin basic protein (4 to 14 residues) as substrate incubated for [gamma-32P]-ATP incubated for 5 mins by scintillation counter analysis
Inhibition of JAK3 (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay relative to control
Inhibition of JAK3 (unknown origin)
Assay data:10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human JAK3 assessed as residual activity at 1 uM relative to control
Inhibition of JAK3 (unknown origin) at 1 uM relative to control
Inhibition of JAK3 (unknown origin) by Z'LYTE assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of JAK3 (unknown origin) incubated for 1 hr in presence of ATP by Z'LYTE assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of JAK1/3 dependent IL-2 stimulated STAT5 phosphorylation in CD3-positive T cells (unknown origin)
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 100 nM incubated for 15 mins by immunoblotting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 0.1 to 10 uM incubated for 15 mins by immunoblotting analysis
Assay data:3 Tested
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