Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19624531.

TBK1 Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:1 Tested

AID:: 1962453

Summary Related BioAssays by Target

Select item 19623062.

TBK1 Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:1 Tested

AID:: 1962306

Summary Related BioAssays by Target

Select item 19451813.

Inhibition of TBK1 phosphorylation in LPS-induced mouse RAW264.7 cells preincubated with compound for 2 hrs followed by LPS stimulation and measured after 6 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:1 Tested

AID:: 1945181

Summary PubMed Citation Related BioAssays by Target

Select item 19146524.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000750a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1914652

Summary Related BioAssays by Target

Select item 19139315.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000701a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1913931

Summary Related BioAssays by Target

Select item 19134766.

Selectivity interaction (Kinase panel (Millipore, radiometric filter-binding assay, conc. ATP = Km)) EUB0000613a TBK1

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913476

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19131647.

Affinity Biochemical interaction (TR-FRET-based kinase activity inhibition assay (1 M ATP)) EUB0000701a TBK1

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:1 Active, 1 Tested

AID:: 1913164

Summary Compounds, Active Related BioAssays by Target

Select item 19131638.

Affinity Biochemical interaction (TR-FRET-based kinase activity inhibition assay (1 M ATP)) EUB0000701a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Active, 1 Tested

AID:: 1913163

Summary Compounds, Active Related BioAssays by Target

Select item 19131599.

Affinity Biochemical interaction (TR-FRET-based kinase activity inhibition assay (1 M ATP)) EUB0000305b TBK1

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913159

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191315810.

Affinity Biochemical interaction (TR-FRET-based kinase activity inhibition assay (1 M ATP)) EUB0000305b IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913158

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191290611.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000701a TBK1

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:1 Tested

AID:: 1912906

Summary Related BioAssays by Target

Select item 191290512.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000701a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1912905

Summary Related BioAssays by Target

Select item 191290113.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000305b TBK1

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912901

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191290014.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000305b IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Active, 1 Tested

AID:: 1912900

Summary Compounds, Active Related BioAssays by Target

Select item 191274215.

Affinity Phenotypic Cellular interaction (pIRF3 cell-based mechanistic assay in MDA-MB231 cells) EUB0000305b TBK1

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912742

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191274116.

Affinity Phenotypic Cellular interaction (pIRF3 cell-based mechanistic assay in MDA-MB231 cells) EUB0000305b IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912741

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 190242117.

Inhibition of TBK1 (unknown origin) at 50 nM by Z'LYTE screening method relative to control

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:3 Tested

AID:: 1902421

Summary PubMed Citation Related BioAssays by Target

Select item 190152818.

Inhibition of human full length recombinant IKKepsilon assessed as residual activity at 1 uM using casein as substrate incubated for 40 mins in presence of [gamma 33P]-ATP by radiometric scintillation counting assay relative to control

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1901528

Summary PubMed Citation Related BioAssays by Target

Select item 189402819.

Inhibition of human TBK1

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894028

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188902520.

Inhibition of TBK1 (unknown origin) at 1.0 uM relative to control

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase TBK1

Assay data:1 Tested

AID:: 1889025

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (4)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (141)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (17)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (112)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (163)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (455)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (78)
BioAssays deposited by other experimentalists

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Related BioAssays, by Target Similarity (List) for PubChem BioAss... (534)
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Structure
NIH_MGC_88
NIH_MGC_88

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Concise Conserved Domain Links for Protein (Select 1779141305) (1)
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