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Inhibition of human caspase 3 using Z-Phe-Arg-AMC as substrate incubated for 30 mins by FRET assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of caspase 3/7 in human 22Rv1 cells by Caspase-Glo reagent based analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of caspase-8 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of caspase-7 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of caspase-3 (unknown origin)
Inhibition of caspase-1 (unknown origin)
Binding affinity to human recombinant caspase 3 at 0.3125 to 5 uM measured after 400 secs by Surface plasmon resonance method
Binding affinity to human caspase 3 in human MDA-MB-231 cells at 5 uM measured after 3 hrs by Cellular thermal shift assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader method
Assay data:8 Active, 38 Tested
Activation of caspase 3 (unknown origin)
Assay data:2 Tested
Inhibition of human recombinant caspase 2 expressed in Escherichia coli at 100 uM using Z-VDVAD-AFC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by measuring amount of AFC formed by spectrofluorimetric method
Inhibition of human recombinant caspase 2 expressed in Escherichia coli using Z-VDVAD-AFC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by measuring amount of AFC formed by spectrofluorimetric method
Inhibition of caspase 1 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of caspase 1 (unknown origin) assessed as enzyme residual activity using YVAD-AFC as substrate at 100 uM by fluorescence analysis
Assay data:33 Tested
Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysis
Inhibition of human caspase 3 using Ac-Asp-Glu-Val-Asp-pNA as substrate by FRET assay
Activation of caspase-3/7 activity in human 518A2 cells at 25 nM preincubated for 24 hrs followed by caspase-3/7 fluorogenic substrate addition and measured after 60 mins by fluorescence assay
Assay data:7 Active, 7 Tested
Activation of caspase-3/7 activity in human 518A2 cells at 1 uM preincubated for 6 hrs followed by caspase-3/7 fluorogenic substrate addition and measured after 60 mins by fluorescence assay
Assay data:1 Active, 1 Tested
Inhibition of human caspase-3 using Ac-Asp-Glu-Val-Asp-pNA as substrate incubated for 60 mins by FRET assay
Activation of caspase 3/7 in human MV4-11 cells incubated for 6 hrs by Caspase-Glo 3/7 reagent based microplate reader analysis
Assay data:32 Active, 27 Activity ≤ 1 µM, 33 Tested
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