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Activity-based Protein Profiling (ABPP) from Article 10.1021/acschembio.5b00514: "Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing."
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of GlpG in Escherichia coli BL21 assessed as inhibition of FP-Rh labeling at 100 uM treated with compound prior to FP-Rh addition by competitive ABPP based analysis
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of GlpG in Escherichia coli BL21 assessed as inhibition of FP-Rh labeling at 200 uM treated with compound prior to FP-Rh addition by competitive ABPP based analysis
Assay data:2 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of GlpG in Escherichia coli BL21 assessed as inhibition of FP-Rh labeling treated with compound for 30 mins prior to FP-Rh addition by competitive ABPP based analysis
Assay data:1 Active, 6 Tested
Competitive inhibition of Bacillus subtilis rhomboid YqgP assessed as residual enzyme activity at 100 uM preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP method
Assay data:9 Tested
Competitive inhibition of Bacillus subtilis rhomboid YqgP at 100 uM preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP method
Assay data:4 Active, 6 Tested
Competitive inhibition of Bacillus subtilis rhomboid YqgP preincubated for 30 mins followed by FP-Rh addition measured after 1 hr by gel-based ABPP method
Assay data:8 Active, 1 Activity ≤ 1 µM, 9 Tested
Binding affinity to recombinant Escherichia coli rhomboid protease GlpG His150 mutant expressed in Escherichia coli C43(DE3) cells by electrospray mass spectrometric analysis
Assay data:1 Active, 1 Tested
Binding affinity to recombinant Escherichia coli rhomboid protease GlpG H254A mutant expressed in Escherichia coli C43(DE3) cells by electrospray mass spectrometric analysis
Assay data:1 Tested
Binding affinity to recombinant Escherichia coli rhomboid protease GlpG S201T mutant expressed in Escherichia coli C43(DE3) cells by electrospray mass spectrometric analysis
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
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