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Inhibition of human SGLT2
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of SGK3 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human SGLT1
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of SGLT1 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of SGLT2 (unknown origin)
Induction of SGK3 degradation in HEK293 cells
Induction of SGK3 degradation in HEK293 cells assessed as maximum degradation at 300 nM after 48 hrs relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Induction of SGK3 degradation in HEK293 cells assessed as maximum degradation after 30 mins relative to control
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000303b SGK1
SummaryRelated BioAssays by Target
Selectivity interaction (Kinase panel (University of Dundee)) EUB0000169b SGK1
Selectivity interaction (Kinase panel (Pfizer) ) EUB0000619a SGK1
Selectivity interaction (Kinase panel (Millipore)) EUB0000153b SGK2
Selectivity interaction (Kinase panel (Millipore)) EUB0000153b SGK1
Inhibition of SGK1 (unknown origin) at 1 uM relative to control
Inhibition of SGK (unknown origin) in presence of ATP
Inhibition of human SGLT1 expressed in CHO cells by methyl-alpha-D-glucopyranoside assay
Assay data:14 Active, 9 Activity ≤ 1 µM, 14 Tested
Inhibition of human SGLT2 expressed in CHO cells by methyl-alpha-D-glucopyranoside assay
Assay data:20 Active, 9 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
Protac activity at VHL/SGK3 in human HEK293 cells at 0.3 mM measured within 8 hrs relative to control
Protac activity at VHL/SGK3 in human HEK293 cells at 0.3 mM measured within 2 hrs relative to control
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