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Enzymatic Activity Assay from US Patent US20230391761: "SUBSTITUTED S-ALANINATE DERIVATIVES"
Assay data:17 Active, 14 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzymatic Activity Assay from US Patent US11584735: "Solid forms of a plasma kallikrein inhibitor and salts thereof"
Assay data:1 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Enzymatic Assay for Thrombin from US Patent US11584714: "MASP-2 inhibitors and methods of use"
Assay data:255 Active, 142 Activity ≤ 1 µM, 453 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Selectivity interaction (Serine protease panel) EUB0000735a PRSS1
SummaryRelated BioAssays by Target
Selectivity interaction (Serine protease panel) EUB0000735a PLAU
Selectivity interaction (Serine protease panel) EUB0000735a F2
Selectivity interaction (Serine protease panel) EUB0000735a CELA1
Inhibition of porcine trypsin at 100 uM using Mes-D-Arg-Gly-Arg-AMC a substrate by fluorescence plate reader analysis
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of bovine thrombin at 100 uM using Tos-Gly-Pro-Arg-AMC as substrate by fluorescence plate reader analysis
Inhibition of human plasma thrombin at 100 uM using Z-Gly-Pro-Arg-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by based spectrofluorimetric method
Inhibition of human plasma thrombin using Z-Gly-Pro-Arg-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by based spectrofluorimetric method
Stability of compound assessed as trypsin (unknown origin)-mediated compound degradation by measuring parent compound remaining at 150 uM measured upto 4 hrs by RP-HPLC method
Assay data:2 Tested
Inhibition of human trypsin
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Covalent inhibition of trypsin (unknown origin) incubated for 1 hr by FRET-based enzymatic assay
Inhibition of native full length human thrombin using Boc-Asp(OBz1)-Pro-Arg-AMC as substrate at 5 uM incubated for 30 mins followed by substrate addition by fluorescence based analysis
Inhibition of bovine thrombin using Tos-Gly-Pro-Arg-AMC as substrate and measured by fluorescence assay
Inhibition of trypsin (unknown origin) using Nalpha-benzoyl-D/L-arginine-4-nitroanilide hydrochloride as substrate preincubated for 5 mins followed by substrate addition and measured upto 30 mins by absorbance based assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human plasma urokinase assessed as remaining enzyme activity using Bz-beta-Ala-Gly-Arg-AMC.AcOH as substrate at 10 uM preincubated for 5 to 15 mins followed by substrate addition and measured at 5 min interval for 2 hrs by fluorescence based envision plate reader method relative to control
Inhibition of human thrombin using H-D-CHA -Ala-Arg-AMC.2AcOH as substrate preincubated for 5 to 15 mins followed by substrate addition and measured at 5 min interval for 2 hrs by fluorescence based envision plate reader method
Stability of compound assessed as trypsin (unknown origin) mediated compound degradation by measuring H-O1WO3LFO6O7-OH level measured at 270 mins by LCMS analysis
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