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Biochemical Assay from US Patent US20240182487: "MACROCYCLES AND THEIR USE"
Assay data:40 Active, 3 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 42 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biological Assay from US Patent US20240182466: "A Crystal Form of a Fluorine-substituted Pyridopyrazole Compound and a Preparation Method Thereof"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
HTRF-Based EGFR Biochemical Assay from US Patent US20240166665: "COVALENT EGFR INHIBITORS AND METHODS OF USE THEREOF"
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibitory Activity Assay from US Patent US11976059: "Isoindolin-1-on derivative, method for preparing same, and pharmaceutical composition comprising same as effective component for preventing or treating cancer"
Assay data:63 Active, 47 Activity ≤ 1 µM, 71 Tested
VEGFR ADP GLO Assay from US Patent US20240109917: "PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS"
Assay data:23 Active, 13 Activity ≤ 1 µM, 485 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
PDGFRβ LanthaScreen Assay from US Patent US20240109917: "PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS"
Assay data:478 Active, 11 Activity ≤ 1 nM, 468 Activity ≤ 1 µM, 485 Tested
PDGFRβ HTRF Assay from US Patent US20240109917: "PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS"
Assay data:485 Active, 377 Activity ≤ 1 nM, 483 Activity ≤ 1 µM, 485 Tested
EGFR Kinase Assay from US Patent US20240083857: "2-Methyl-Quinazolines"
Assay data:5 Active, 2 Activity ≤ 1 µM, 301 Tested
Mobility-Shift Assay from US Patent US11912663: "Multi-targeted tyrosine kinase inhibitors and their pharmaceutical uses"
Assay data:14 Active, 15 Activity ≤ 1 µM, 15 Tested
In Vitro Kinase Binding Assay from US Patent US20240058459: "DENDRIMER COMPOSITIONS AND METHODS FOR DRUG DELIVERY TO THE EYE"
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
TBD from US Patent US20240034743: "TRICYCLIC COMPOUNDS AS EGFR INHIBITORS"
Assay data:135 Active, 118 Activity ≤ 1 nM, 137 Activity ≤ 1 µM, 137 Tested
Assay data:133 Active, 31 Activity ≤ 1 nM, 137 Activity ≤ 1 µM, 137 Tested
Safety47 Scan (DiscoverX - Eurofins)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Protein Tyrosine Kinase, EGF Receptor Eurofins Panlabs panel
KDR Invitrogen Lab (UK) kinase screen (BI)
EGFR Invitrogen Lab (UK) kinase screen (BI)
Compound was evaluated for inhibition of human KDR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:12 Active, 3 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 101 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:19 Active, 11 Activity ≤ 1 µM, 692 Tested
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