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Chymotrypsin Serine protease panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to recombinant human chymotrypsin assessed as increase in fluorescence using H2-OPT as substrate at 1 uM by SDS-PAGE based gel fluorescence scanning analysis
Assay data:3 Active, 6 Tested
Inhibition of human 20S proteasome
Assay data:1 Active, 2 Tested
Stability of the compound assessed as chymotrypsin (unknown origin)-mediated drug degradation at 100 uM measured after 3 hrs by MALDI-TOF-MS analysis
Assay data:1 Active, 1 Tested
Stability of the compound assessed as chymotrypsin (unknown origin)-mediated drug degradation by measuring residual ratio at 100 uM measured after 1 hr by MALDI-TOF-MS analysis
Stability of the compound assessed as chymotrypsin (unknown origin)-mediated drug degradation by measuring cleavage at Leu21-Arg22 residue at 100 uM measured for 3 hrs by MALDI-TOF-MS analysis
Stability of the compound assessed as chymotrypsin (unknown origin)-mediated drug degradation by measuring cleavage at Tyr7-Ser8 residue at 100 uM measured for 3 hrs by MALDI-TOF-MS analysis
Inhibition of 20S proteasome (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of beta 1 proteasome (unknown origin)
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Activation of human 20S proteosome at chymotrypsin like site assessed as maximum fold change in substrate degradation using Suc-LLVY-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis relative to control
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of human 20S proteosome at chymotrypsin like site assessed as substrate degradation using Suc-LLVY-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis
Assay data:7 Active, 1 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of human 20S proteosome at trypsin-like site assessed as maximum fold change in substrate degradation using Boc-LLR-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis relative to control
Assay data:8 Tested
Activation of human 20S proteosome at trypsin-like site assessed as substrate degradation using Boc-LLR-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis
Activation of human 20S proteosome at caspase-like site assessed as maximum fold change in substrate degradation using Z-LLE-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis relative to control
Assay data:6 Tested
Activation of human 20S proteosome at caspase-like site assessed as substrate degradation using Z-LLE-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis
Assay data:6 Active, 17 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of human 20S proteosome assessed as maximum fold change in substrate degradation using Suc-LLVY-AMC/Z-LLE-AMC/Boc-LLR-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis relative to control
Assay data:9 Tested
Activation of human 20S proteosome assessed as substrate degradation using Suc-LLVY-AMC/Z-LLE-AMC/Boc-LLR-AMC as flurogenic substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by spectrometric analysis
Inhibition of human pancreas chymotrypsin at 100 uM using Suc-Ala-Ala-Pro-Phe-AMC as substrate preincubated for 15 mins incubated followed by addition of substrate measured after 60 mins by measuring amount of AMC formed by spectrofluorimetric method
Inhibition of human pancreas chymotrypsin using Suc-Ala-Ala-Pro-Phe-AMC as substrate preincubated for 15 mins incubated followed by addition of substrate measured after 60 mins by measuring amount of AMC formed by spectrofluorimetric method
Inhibition of 20S proteasome subunit beta-1c (unknown origin) using Z-LLE-AMC as substrate and measured after 30 mins
Assay data:3 Tested
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