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PI3K-delta Scintillation Proximity Assay from US Patent US11926616: "Aminopyrazine diol compounds as PI3K-γ inhibitors"
Assay data:46 Active, 43 Activity ≤ 1 µM, 46 Tested
SummaryRelated BioAssays by Target
Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by ATP and substate addition and measured after 1 hr by ADP-glo reagent based assay
Assay data:2 Active, 5 Tested
Inhibition of PI3K-P85 phosphorylation in human HT-29 cells at 4 uM incubated for 72 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Inhibition of PI3K-P85 phosphorylation in human HT-29 cells at 2 uM incubated for 72 hrs by Western blot analysis
Inhibition of PI3K-P85 phosphorylation in human HT-29 cells at 1 uM incubated for 72 hrs by Western blot analysis
Antagonist activity at PI3Kdelta (unknown origin) using PIP2 as substrate in presence of ATP incubated for 30 to 60 mins by ADP-glo based luminescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at PI3Kdelta (unknown origin) assessed as inhibition rate at 20 nM using PIP2 as substrate in presence of ATP incubated for 30 to 60 mins by ADP-glo based luminescence assay relative to control
Assay data:29 Tested
Inhibition of PI3Kdelta (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of PI3K-delta (unknown origin)
Inhibition of recombinant PI3K p110alpha/p85 (unknown origin) incubated for 1 hr in presence of gamma[33P]ATP by scintillation counting analysis
Inhibition of human PI3K-delta using PIP2 as substrate in presence of gamma[32P]ATP
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of PI3Kdelta (unknown origin) preincubated for 10 mins followed by ATP addition and measured after 60 mins by ADP-Glo assay
Assay data:1 Tested
Inhibition of PI3Kdelta (unknown origin) in presence of 75 uM ATP
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of PI3Kdelta (unknown origin) at 0.1 uM relative to control
Inhibition of PI3Kdelta (unknown origin) by ADP Glo luminescent assay
Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 25 Tested
Inhibition of PI3Kdelta (unknown origin) at 1 uM
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to PI3Kdelta (unknown origin) assessed as dissociation constant
Assay data:1 Activity ≤ 1 µM, 1 Tested
Inhibition of human P13Kalpha
Inhibition of PI3 kinase p110alpha/p85alpha (unknown origin) at 1 uM relative to control
Inhibition of PI3 Kinase p110delta/p85alpha (unknown origin) at 1 uM relative to control
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