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EMSA assay for RPA-DNA inhibition activity from US Patent US10774063: "Materials and method for inhibiting replication protein A and uses thereof"
Assay data:12 Tested
SummaryRelated BioAssays by Target
In Vitro Assay from US Patent US9533969: "Materials and method for inhibiting replication protein A and uses thereof"
Assay data:6 Tested
Binding affinity to RPA70 (unknown origin) by FITC-labeled probe based fluorescence polarization anisotropy
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human recombinant RPA70 expressed in Escherichia coli BL21 using FPA by tryptophan fluorescence quenching assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of GST-tagged X-rhodamine-labelled p53TAD2 binding to human recombinant RPA70 expressed in Escherichia coli BL21 by fluorescence anisotropy competition assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of FITC-ATRIP/FITC-ATRIP2 peptide probe from RPA70N protein (unknown origin) at 500 uM incubated for 1 hr by fluorescence polarization anisotropy assay
Assay data:9 Tested
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisotropy assay
Assay data:34 Active, 3 Activity ≤ 1 nM, 47 Activity ≤ 1 µM, 47 Tested
Binding affinity to RPA70N protein (unknown origin) by HSQC NMR-based titration method
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of purified full length RPA70 (unknown origin) binding to radiolabelled single strand DNA at 0.1 to 100 uM after 20 mins by electrophoretic mobility shift assay
Selectivity ratio of Kd for recombinant human RPA70 A/B region (181 to 422 amino acids) expressed in Escherichia coli Rosetta to Kd for human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3
Binding affinity to recombinant human RPA70 A/B region (181 to 422 amino acids) expressed in Escherichia coli Rosetta by fluorescence polarization anisotropy assay
Assay data:1 Active, 2 Tested
Binding affinity to recombinant human RPA70 N-terminal domain (1 to 120 amino acids) expressed in Escherichia coli BL21-DE3 by fluorescence polarization anisotropy assay
Assay data:19 Active, 8 Activity ≤ 1 µM, 42 Tested
Binding affinity to RPA70N (1 to 120) site1 (unknown origin) expressed in Escherichia coli BL21-DE3 cells by NMR spectroscopy
Assay data:4 Tested
Binding affinity to RPA70N (1 to 120) site2 (unknown origin) expressed in Escherichia coli BL21-DE3 cells by NMR spectroscopy
Binding affinity to RPA70N (1 to 120) (unknown origin) expressed in Escherichia coli BL21-DE3 cells by FPA assay
Displacement of FITC-ATRIP2 from RPA70N (1 to 120) (unknown origin) by FPA assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of FITC-ATRIP2 from RPA70NAB domain (unknown origin) by FPA assay
Displacement of FITC-ss-DNA from RPA70NAB domain (unknown origin) by FPA assay
Displacement of FITC-ss-DNA from RPA70AB domain (unknown origin) by FPA assay
Selectivity ratio of Kd for displacement of FITC-ss-DNA from RPA70NAB domain (unknown origin) to Kd for displacement of FITC-ATRIP2 from FITC-ATRIP2 from RPA70N (1 to 120) (unknown origin)
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