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Inhibition of Beta-Lactamase Enzymes from US Patent US10800778: "Beta-lactamase inhibitor compounds"
Assay data:39 Active, 1 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Test for beta-lactamase Inhibitory Activity from US Patent US10544146: "Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Cell Free Inhibition Assay from US Patent US9120808: "Substituted clavulanic acid"
Assay data:38 Active, 3 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 42 Tested
Inhibition Assay from US Patent US9035062: "Process for preparing a compound useful for producing an optically active diazabicyclooctane compound"
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Steady-State Kinetics Assay from Article 10.1021/bi501197t: "Detecting a quasi-stable imine species on the reaction pathway of SHV-1 -lactamase and 6 -(hydroxymethyl)penicillanic acid sulfone."
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition Assay from Article 10.1016/S1074-5521(01)00034-5: "Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase."
Assay data:33 Active, 17 Activity ≤ 1 µM, 41 Tested
Enzyme Inhibition Assay from Article 10.1016/S1074-5521(00)00052-1: "Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases."
Assay data:11 Active, 10 Activity ≤ 1 µM, 14 Tested
Beta-lactamase AmpC Inhibition Assay from Article 10.1038/nchembio.155: "Molecular docking and ligand specificity in fragment-based inhibitor discovery."
Assay data:8 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of bacterial Beta-lactamase TEM-1 (24 - 286) (unknown origin) expressed in Escherichia coli Transetta (DE3)
Assay data:10 Active, 2 Activity ≤ 1 µM, 22 Tested
Binding affinity to Enterobacter cloacae P99 beta-lactamase assessed as increase in molecular weight of enzyme-compound complex by mass-spectra analysis (Rvb = 39192 Da)
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Irreversible inhibition of Enterobacter cloacae P99 beta-lactamase using cephalothin as substrate by spectrophotometric analysis
Assay data:7 Tested
Irreversible inhibition of Enterobacter cloacae P99 beta-lactamase assessed as ratio of K2/K3 using cephalothin as substrate by spectrophotometric analysis
Irreversible inhibition of Enterobacter cloacae P99 beta-lactamase assessed as second-order rate constant for enzyme-inhibitor complex using cephalothin as substrate by spectrophotometric analysis
Inhibition of bacterial wild type Beta-lactamase TEM-1 pre-incubated for 5 mins before addition of chromogenic beta-lactamase substrate CENTA by spectrophotometry
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to bacterial wild type Beta-lactamase TEM-1 assessed as change in melting temperature at 100-fold molar excess compound concentration relative to apo-enzymes by SYPRO Orange dye based differential scanning fluorimetry
Assay data:1 Tested
Inhibition of Escherichia coli TEM-1 beta-lactamase
Inhibition of beta-lactamase TEM-1 in Escherichia coli GN5482 assessed as potentiation of ceftazidime-induced antibacterial activity by measuring ceftazidime MIC (Rvb = 4 ug/ml)
Inhibition of bacterial N-terminal His-tagged TEV protease site linked TEM-1 (24 to 286 amino acids) expressed in Escherichia coli Transetta (DE3) preincubated for 10 mins followed by FC5 fluorescent substrate addition by fluorescence assay
Assay data:7 Active, 1 Activity ≤ 1 µM, 35 Tested
Inhibition of bacterial beta lactamase TEM-1 after 5 mins
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of bacterial beta lactamase TEM-1
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