Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Biological Assay from US Patent US11701373: "Substituted bicyclic compounds"
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
GPCR beta-arrestin recruitment assay with target: S1PR1 Assay Type: PRESTO-Tango Concentration: 0.0000004
Assay data:211 Tested
SummaryRelated BioAssays by Target
GPCR beta-arrestin recruitment assay with target: S1PR1 Assay Type: PRESTO-Tango Concentration: 0.000002
GPCR beta-arrestin recruitment assay with target: S1PR1 Assay Type: PRESTO-Tango Concentration: 0.00001
Assay data:437 Tested
Agonist activity at S1P1 receptor (unknown origin) expressed in PathHunter HEK 293 EDG1 Total GPCR Internalization cells assessed as receptor internalization incubated for 90 mins by measuring chemiluminescence signal by microplate reader method
Assay data:43 Active, 2 Activity ≤ 1 nM, 65 Activity ≤ 1 µM, 65 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at S1P1 receptor (unknown origin) expressed in PathHunter CHO-K1 EDG1 beta-arrestin cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by measuring chemiluminescence signal by microplate reader method
Assay data:42 Active, 65 Activity ≤ 1 µM, 65 Tested
Binding affinity to recombinant human S1PR1 expressed in cell membrane
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of S1PR1 (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to S1PR1 (unknown origin) by SPR assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [32P]S1P from human recombinant S1PR1 incubated for 60 mins by competitive binding assay based scintillation counter
Assay data:1 Active, 8 Activity ≤ 1 µM, 8 Tested
Binding affinity to S1PR1 (unknown origin) assessed as dissociation constant by surface plasmon resonance analysis
Assay data:8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of calcium flux
Assay data:4 Tested
Homogenous Time-Resolved Fluorescence (HTRF) Assay for Direct cAMP Measurement from US Patent US11149292: "Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Receptor [35S] GTPgammaS Binding Assays from US Patent US11059784: "Oxime ether compounds"
Assay data:28 Active, 27 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
S1P1 Binding Assay from US Patent US11059784: "Oxime ether compounds"
Assay data:27 Active, 23 Activity ≤ 1 µM, 27 Tested
Receptor [35S] GTPgammaS Binding Assays: (S1P1 GTPgammaS/S1P3 GTPgammaS) from US Patent US11058696: "Substituted bicyclic compounds"
Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
S1P1 Binding Assay from US Patent US11058696: "Substituted bicyclic compounds"
S1P1 Binding Assay from US Patent US11046646: "Alkylphenyl compounds"
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
Competition Binding Assay from US Patent US11034691: "Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders"
Assay data:355 Active, 260 Activity ≤ 1 µM, 366 Tested
In Vitro Functional Activity (Agonism) on Human S1P1 Receptors (Method B) from US Patent US10807991: "Spiro-cyclic amine derivatives as S1P modulators"
Assay data:1 Active, 14 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on