Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19146521.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000750a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1914652

Summary Related BioAssays by Target

Select item 19139312.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000701a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1913931

Summary Related BioAssays by Target

Select item 19131633.

Affinity Biochemical interaction (TR-FRET-based kinase activity inhibition assay (1 M ATP)) EUB0000701a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Active, 1 Tested

AID:: 1913163

Summary Compounds, Active Related BioAssays by Target

Select item 19131584.

Affinity Biochemical interaction (TR-FRET-based kinase activity inhibition assay (1 M ATP)) EUB0000305b IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913158

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19129055.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000701a IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1912905

Summary Related BioAssays by Target

Select item 19129006.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000305b IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Active, 1 Tested

AID:: 1912900

Summary Compounds, Active Related BioAssays by Target

Select item 19127417.

Affinity Phenotypic Cellular interaction (pIRF3 cell-based mechanistic assay in MDA-MB231 cells) EUB0000305b IKBKE

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912741

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19015288.

Inhibition of human full length recombinant IKKepsilon assessed as residual activity at 1 uM using casein as substrate incubated for 40 mins in presence of [gamma 33P]-ATP by radiometric scintillation counting assay relative to control

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1901528

Summary PubMed Citation Related BioAssays by Target

Select item 18760159.

Inhibition of IKK epsilon (unknown origin)

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1876015

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 183558710.

IKK-epsilon DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1835587

Summary Related BioAssays by Target

Select item 183500011.

IKKepsilon(h) Kinase panel

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1835000

Summary Related BioAssays by Target

Select item 183417012.

Inhibition of IKKepsilon (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:1 Tested

AID:: 1834170

Summary PubMed Citation Related BioAssays by Target

Select item 182379113.

Inhibition of full length recombinant human IKKepsilon using casein as substrate incubated for 40 mins in presence of [gamma-33P-ATP] by radiometric scintillation assay

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested

AID:: 1823791

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 180680014.

IKKe Biochemical Assay from US Patent US11440899: "Pyrimidine TBK/IKKe inhibitor compounds and uses thereof"

Source:: BindingDB

Protein Targets:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon; ...
Total:: 1

Assay data:98 Active, 95 Activity ≤ 1 µM, 98 Tested

AID:: 1806800

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180457115.

Caliper Kinase Assay from US Patent US10676460: "Quinazolines as potassium ion channel inhibitors"

Source:: BindingDB

Protein Targets:: Aurora kinase A; ...
Total:: 21

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1804571

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180337416.

Time-Resolved Fluorescence-based Lanthascreen Assay from US Patent US9433622: "Pyrimidine compounds useful in the treatment of diseases mediated by IKKE and/or TBK1 mechanisms"

Source:: BindingDB

Protein Targets:: Serine/threonine-protein kinase TBK1; ...
Total:: 2

Assay data:165 Active, 165 Activity ≤ 1 µM, 165 Tested

AID:: 1803374

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180231817.

IKKepsilon Flashplate Assay from US Patent US9273029: "Pyridine-and pyrazine derivatives"

Source:: BindingDB

Assay data:51 Active, 33 Activity ≤ 1 µM, 51 Tested

AID:: 1802318

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180220218.

IKKε Kinase Assay from US Patent US9249114: "Thiazole derivatives"

Source:: BindingDB

Assay data:27 Active, 19 Activity ≤ 1 µM, 27 Tested

AID:: 1802202

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 180093419.

Time-Resolved Fluorescence-based Lanthascreen Assay from US Patent US8962609: "Pyrimidine compounds as inhibitors of protein kinases IKK epsilon and/or TBK-1, processes for their preparation, and pharmaceutical compositions containing them"

Source:: BindingDB

Protein Targets:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon; ...
Total:: 2

Assay data:72 Active, 61 Activity ≤ 1 µM, 72 Tested

AID:: 1800934

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180088220.

Flashplate Assay from US Patent US8969335: "Benzonitrile derivatives as kinase inhibitors"

Source:: BindingDB

Protein Targets:: Inhibitor of nuclear factor kappa-B kinase subunit epsilon; ...
Total:: 2

Assay data:95 Active, 1 Activity ≤ 1 nM, 93 Activity ≤ 1 µM, 95 Tested

AID:: 1800882

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

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Proteins (3)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (58)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (9)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (47)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (209)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (37)
BioAssays deposited by other experimentalists

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Related BioAssays, by Target Similarity (List) for PubChem BioAss... (247)
Related BioAssays, by Target Similarity (List) for PubChem BioAssay (Select 1806800)
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Compounds, Active for PubChem BioAssay (Select 1802318) (51)
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Compounds, Active for PubChem BioAssay (Select 1876015) (1)
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Full text in PMC (nucleotide) for Gene (Select 854630) (9)
PMC
inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [Homo sapi...
inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [Homo sapiens]
gi|2462515646|ref|XP_054195702.1|

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