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Biological Assays gainst IRAK1 from US Patent US20240043405: "POTENT AND SELECTIVE IRREVERSIBLE INHIBITORS OF IRAK1"
Assay data:21 Active, 20 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human IRAK1 using biotinylated FGLARFSRFAGSSPSQSSMVARTQTVRGT peptide as substrate incubated for 1 hr in presence of ATP by ELISA assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of IRAK1 (unknown origin) by Ambit kinase assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of IRAK1 (unknown origin)
Inhibition of IRAK1 (unknown origin) in presence of 25 uM ATP
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of IRAK-1 (unknown origin)
Kinase Inhibitory Assay from US Patent US20230303563: "MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF"
Assay data:91 Active, 87 Activity ≤ 1 nM, 91 Activity ≤ 1 µM, 91 Tested
IC50 Kinase Assays from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:50 Active, 8 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 50 Tested
Kinase Assay from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:8 Active, 7 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
HotSpot Assay from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:30 Active, 6 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 30 Tested
Z′-LYTE Kinase Assay from US Patent US11542251: "IRAK degraders and uses thereof"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
IRAK1 Enzymatic Assay from US Patent US11542246: "Quinoline compounds as IRAK inhibitors and uses thereof"
Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000596aBDA IRAK1
Inhibition of IRAK1 (unknown origin) at 1 uM by kinase-profiling analysis
Inhibition of IRAK1 (unknown origin) by biochemical assay
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
IRAK1 DiscoveRx kinase panel
SummaryRelated BioAssays by Target
IRAK1(h) Kinase panel
IRAK1(h) Millipore kinase panel
Inhibition of IRAK1 (unknown origin) at 1 uM
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