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Summary
Selectivity interaction (Serine protease panel) EUB0000735a CTRC
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human pancreas chymotrypsin at 100 uM using Suc-Ala-Ala-Pro-Phe-AMC as substrate preincubated for 15 mins incubated followed by addition of substrate measured after 60 mins by measuring amount of AMC formed by spectrofluorimetric method
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human pancreas chymotrypsin using Suc-Ala-Ala-Pro-Phe-AMC as substrate preincubated for 15 mins incubated followed by addition of substrate measured after 60 mins by measuring amount of AMC formed by spectrofluorimetric method
Inhibition of human Chymotrypsin at 20 uM using Suc-Ala-Ala-Pro-Phe-NHMec as fluorogenic substrate preincubated for 15 mins followed by substrate addition by spectrophotometry analysis
Binding affinity to human chymotrypsin assessed as inhibition constant using 3-Carbomethoxypropionyl-L-arginyl-Lprolyl-L-tyrosine p-Nitroaniline as substrate measured upto 120 mins by spectrophotometric analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Stability of the compound in PBS at pH 7.4 assessed as chymotrypsin (unknown origin)-mediated proteolysis by measuring remaining compound after 12 hrs by HPLC analysis
Assay data:2 Tested
Chromogenic Enzyme Activity Assays from US Patent US11149067: "Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors"
Assay data:31 Active, 19 Activity ≤ 1 µM, 33 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Proteasome-Activity Inhibitory Assay from US Patent US10640533: "Epoxyketone compounds for enzyme inhibition"
Assay data:18 Active, 2 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
α-Chymotrypsin Inhibition Kinetic Assay from Article 10.1016/j.bioorg.2017.01.001: "Synthesis, structure-activity relationships studies of benzoxazinone derivatives as a-chymotrypsin inhibitors."
Assay data:6 Active, 19 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
α-Chymotrypsin Inhibition Assay from Article 10.1016/j.bioorg.2017.01.001: "Synthesis, structure-activity relationships studies of benzoxazinone derivatives as a-chymotrypsin inhibitors."
Assay data:3 Active, 30 Tested
Fluorescence Assay from Article 10.1021/cc700189b: "Diversity-oriented fluorescence library approach (DOFLA) to the discovery of chymotrypsin sensor."
Assay data:7 Tested
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