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Binding affinity towards human NTSR1 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:2 Active, 294 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human NTR1
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes assessed as amount of blocking at 10 nM incubated for 120 mins by radioligand depletion assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes assessed as amount of blocking at 1 uM incubated for 120 mins by radioligand depletion assay
Assay data:4 Tested
Displacement of [3H]NT(8-13) from human NTSR1 F2.65C mutant expressed in HEK293 cell membranes by radioligand displacement assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Displacement of [3H]neurotensin from human NTSR1 expressed in CHO cell membranes by radioligand depletion assay
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
NT1 (h) (NTS1) CEREP panel
SummaryRelated BioAssays by Target
Radioligand Binding Assay NTR1 from US Patent US10799605: "Conjugate comprising a neurotensin receptor ligand and use thereof"
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Functional Ca2+ Mobilisation Assay from US Patent US10799605: "Conjugate comprising a neurotensin receptor ligand and use thereof"
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
NTR1 Ca2+ Flux Dose Response from US Patent US10584103: "Small molecule agonists of neurotensin receptor 1"
Assay data:131 Active, 20 Activity ≤ 1 µM, 211 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
SPR Screening Assay from Article 10.1021/acschembio.6b00646: "Ligand Discovery for a Peptide-Binding GPCR by Structure-Based Screening of Fragment- and Lead-Like Chemical Libraries."
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:5 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 7 Tested
NTR1 Ca2+ Flux Dose Response from US Patent US10118902: "Small molecule agonists of neurotensin receptor 1"
Assay data:131 Active, 20 Activity ≤ 1 µM, 210 Tested
Neurotensin NT1 Eurofins-Panlabs radioligand binding assay
Assay data:3 Tested
PRESTO-Tango GPCRome screening (NTSR1)
NT1 (NTS1) CEREP ligand profiling
Neurotensin receptor (h) CEREP ligand profiling
NT1 (h) Ligand binding assay
NT1 (h) CEREP ligand profiling
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