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Thermal Shift Assay. Domain: start/stop: M1-S424
Assay data:27 Tested
SummaryRelated BioAssays by Target
MRCKB DiscoveRx kinase panel
Assay data:1 Tested
MRCKA DiscoveRx kinase panel
MRCKbeta(h) Kinase panel
MRCKalpha(h) Kinase panel
Inhibition of MRCKbeta (unknown origin) at 1 uM
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MRCKalpha (unknown origin) at 1 uM
Kinase Assay from US Patent US11447505: "Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer"
Assay data:225 Active, 76 Activity ≤ 1 nM, 225 Activity ≤ 1 µM, 225 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding Assay from Article 10.1074/jbc.M707463200: "Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta."
Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
MRCK Inhibition Assay from Article 10.1021/jm800986w: "Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors."
Assay data:5 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
KinomeScan assay: inhibition of MRCKB
Assay data:108 Tested
KinomeScan assay: inhibition of MRCKA
MRCKalpha(CD4ALGY1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
MRCKbeta(h) Eurofins kinase panel
MRCKalpha(h) Eurofins kinase panel
CDC42BPB ProQinase selectivity panel
CDC42BPA ProQinase selectivity panel
CDC42 BPB (MRCKB) Kinase screen
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