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Inhibition of GPX4 in human A549 cells assessed as decrease in GPX4 protein activity at 5 to 20 uM for 24 hrs by Western blotting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to GPX4 in human NCI-H522 cells assessed as increase in aggregation temperature at 0.5 uM incubated for 1 hr by CETSA analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to GPX4 in human NCI-H522 cells at 10 uM incubated for 1 hr by Biotin-TAMRA pull down based western blot analysis
Binding affinity to GPX4 in human NCI-H522 cells at 10 uM incubated for 1 hr by Biotin-TAMRA pull down based mass spectrometry
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of GPX4 in human ES2 cells at 10 uM measured after 1 hr by phosphotidylcholine hydroperoxide (PCOOH) LC-MS based assay relative to control
SummaryRelated BioAssays by Target
Inhibition of GPX4 in human 4T1 cells at 1 uM incubated for 1 hr relative to control
Assay data:27 Tested
Inhibition of GPX4 in human 4T1 cells assessed as decrease in intracellular GPX4 activity at 5 uM after 6 hrs
Assay data:2 Tested
Inhibition of GPX4 in human 4T1 cells assessed as induction of loss of intracellular GPX4 activity incubated for 8 hrs by Western blot analysis
Assay data:2 Active, 2 Tested
In vivo inhibition of GPX4 in human MCF7 cells xenografted in BALB/c mouse at 25 to 50 mg/kg, ip administered once for 17 days by immunofluorescence analysis
Inhibition of GPX4 in human MCF7 cells assessed as increase in GPX4 degradation incubated for 48 hrs by Western blot analysis
Assay data:1 Active, 2 Tested
Binding affinity in GPX4 in human MCF7 cells assessed as increase in stability in 60 and 65 degreeC at 100 uM by cellular thermal shift assay
Binding affinity to GPX4 in human PANC-1 cells assessed as protein destabilization by measuring reduction in melting temperature at 100 uM measured after 1 hr by thermal shift assay
Binding affinity to GPX4 in human MIA PaCa-2 cells assessed as protein destabilization by measuring melting temperature at 100 uM measured after 1 hr by thermal shift assay (Rvb = 60.34 degreeC)
Covalent binding affinity to GPX4 (unknown origin) by Western blot analysis
Binding affinity to GPX4 (unknown origin) by CETSA
Selectivity ratio of EC50 for Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability in presence of ferrostatin-1 to EC50 for Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability
Assay data:16 Tested
Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability in presence of ferrostatin-1
Assay data:7 Active, 48 Tested
Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability
Assay data:15 Active, 10 Activity ≤ 1 µM, 48 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to GPX4 (unknown origin)
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