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Antagonist activity against human integrin alphaVbeta3 expressed in CHO-K1 cells measured after 4 hrs by Cell adhesion assay
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant integrin alphavbeta3 incubated for 1 hr by ELISA assay
Assay data:1 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at human alphaVbeta3 Integrin assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of alpha2bbeta3 integrin receptor expressed on human surface of platelets
Assay data:3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to fibrinogen in human HEK293 cells
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to fibrinogen in human SK-OV-3 cells expressing alphavbeta5 integrin receptor
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human A549 cells preincubated for 30 mins followed by VN substrate addition and measured after 1 hr by crystal violet based staining method
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human WM 266-4 cells preincubated for 30 mins followed by VN substrate addition and measured after 1 hr by crystal violet based staining method
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Solid Phase Receptor Assay (SPRA) for alphavbeta3 Function from US Patent US10577330: "Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists"
Assay data:28 Active, 3 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Affinity Assay from US Patent US9345793: "Compounds for binding to the platelet specific glycoprotein IIB/IIIA and their use for imaging of thrombi"
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding Assay from US Patent US8927534: "Compounds for the inhibition of integrins and use thereof"
Assay data:12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Assay from US Patent US9744252: "Compounds for binding to the platelet specific glycoprotein IIb/IIIa and their use for imaging of thrombi"
Solid Phase Receptor Assay (SPRA) for alphaVbeta3 from US Patent US10035778: "Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists"
Assay data:17 Active, 3 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Inhibition of fibrinogen binding to rat platelet integrin alpha2b beta3 at 1 ug/ml by ELISA based solid phase binding assay
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of fibrinogen binding to rat platelet integrin alpha2b beta3 by ELISA based solid phase binding assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to integrin alphavbeta3 receptor (unknown origin) in presence of fibrinogen incubated for 2 hrs by competitive binding assay
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to integrin alphaVbeta3 expressed in human M21 cells at 250 uM incubated for 30 mins by confocal microscopy
Assay data:1 Active, 1 Tested
Binding affinity to human integrin alpha2bbeta3 incubated for 1 hr by ELISA based solid phase integrin binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 7 Tested
Binding affinity to human integrin alphaVbeta3 incubated for 1 hr by ELISA based solid phase integrin binding assay
Assay data:16 Active, 12 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested
Inhibition of human alphavbeta3 integrin stably expressed in human K562 cells assessed as inhibition of cell adhesion to GST-LAP1 incubated for 30 mins by BCECF-AM staining based fluorescence assay
Assay data:2 Active, 6 Tested
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