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Purinergic P2X Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Lead profiling screen (Eurofins, GPCRs, ion channels, kinases and transporters)) EUB0000309b P2RX1
Inhibition of P2X1 receptor (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at human P2X1R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by compound addition and further incubated for 30 mins in presence of ATP by multimode plate reader analysis
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human P2X1R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by compound addition and further incubated for 30 mins in presence of ATP by multimode plate reader analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human P2X1R transfected in CHO-K1 cells at 30 uM preincubated for 30 mins followed by alpha,beta-meATP addition by luminescence based assay relative to control
Assay data:20 Tested
Antagonist activity at human P2X1R transfected in CHO-K1 cells preincubated for 30 mins followed by alpha,beta-meATP addition by luminescence based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Antagonist activity at human P2X1R expressed in HEK293 cells assessed as reduction in intracellular Ca2+ influx at 10 uM pretreated with Fluo-4 for 1 hr followed by compound addition and further incubated for 30 mins in presence of ATP by multimode plate reader analysis relative to control
Assay data:4 Tested
Antagonist activity at P2X1 receptor (unknown origin)
Purinergic P2X Eurofins-Panlabs radioligand binding assay
Assay data:5 Tested
P2X Eurofins-Cerep binding assay
Assay data:2 Tested
P2X CEREP ligand profiling
P2X-purinergic receptor CEREP ligand profiling
P2X Ligand binding assay
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