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Urokinase Serine protease panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of Urokinase (unknown origin)
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Selectivity interaction (Serine protease panel) EUB0000735a PLAU
Inhibition of human plasma urokinase assessed as remaining enzyme activity using Bz-beta-Ala-Gly-Arg-AMC.AcOH as substrate at 10 uM preincubated for 5 to 15 mins followed by substrate addition and measured at 5 min interval for 2 hrs by fluorescence based envision plate reader method relative to control
Inhibition of urokinase plasminogen activator in human MCF7 cells measured after 24 hrs by ELISA method
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of uPAR/uPA (unknown origin) interaction assessed as dissociation constant by fluorescence polarization (FP) assay
Assay data:7 Active, 1 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of uPAR/uPA (unknown origin) interaction by ELISA
Assay data:5 Active, 8 Tested
Inhibition of uPA (unknown origin) using L-pyroglutamyl-glycyl-L-arginine-p-nitroanilide as substrate by Lineweaver-Burk plot analysis
Assay data:1 Active, 1 Tested
Inhibition of human uPA using Z-Gly-Gly-Arg-AMC as substrate measured for 15 mins by fluorometric assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of mouse uPA using Z-Gly-Gly-Arg-AMC as substrate measured for 15 mins by fluorometric assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of Urokinase-type plasminogen activator (unknown origin)
Assay data:3 Tested
Binding affinity to human urokinase assessed as inhibition constant using L-Pyroglutamyl-glycyl-L-arginine p-Nitroaniline as substrate upto 120 mins by spectrophotometric analysis
Urokinase Amidolytic Assay from Article 10.3109/14756366.2011.651463: "Tripeptides with non-code amino acids as potential serine proteases inhibitors."
Assay data:8 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Assay from Article 10.3109/14756366.2010.616860: "Polyphenol fatty acid esters as serine protease inhibitors: a quantum-chemical QSAR analysis."
Assay data:9 Active, 25 Tested
Antiamidolytic Assay from Article 10.3109/14756360903389872: "Carbocyclic potential DNA minor groove binders and their biological evaluation."
Assay data:1 Active, 5 Tested
Amidolytic Activity Assay (Urokinase) from Article 10.3109/14756360903049042: "Synthesis and activity of amides of tripeptides as potential urokinase inhibitors."
Assay data:1 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Photometric_Method1 from Article : "Abbott Urokinase"
Assay data:35 Active, 1 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 46 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Fluorescence Polarization Assay from Article 10.1021/acs.biochem.6b01039: "Small Molecules Engage Hot Spots through Cooperative Binding To Inhibit a Tight Protein-Protein Interaction."
Assay data:33 Active, 6 Activity ≤ 1 µM, 42 Tested
Enzymatic Assay from Article 10.1074/jbc.M109.067967: "Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1."
Assay data:12 Active, 9 Activity ≤ 1 µM, 13 Tested
Abbott uPA__Urokinase Human - Ki(uM) from Article : "UROKINASE in CSAR_FULL_RELEASE_3JULY2012"
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