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Inhibition of human recombinant LIMK1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of LIMK1 (unknown origin) phosphorylation of cofilin
Inhibition of LIMK1 (unknown origin)
Assay data:7 Active, 7 Activity ≤ 1 µM, 8 Tested
Inhibition of human recombinant LIMK1 in presence of ATP cofilin as substrate at 25 uM
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of human LIMK1 (321 to 647 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid method
Assay data:15 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 19 Tested
In Vitro Assay from US Patent US20230312576: "4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER"
Assay data:118 Active, 114 Activity ≤ 1 µM, 118 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (DSF assay) EUB0000285b LIMK1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (ScanMAX (DiscoverX, competition-binding assay)) EUB0000232b LIMK1
Selectivity interaction (Kinobead pulldown assay ) EUB0000232b LIMK1
Selectivity interaction (DSF assay) EUB0000232b LIMK1
Affinity Biochemical interaction (RapidFire MS assay) EUB0000285b LIMK1
Affinity Biochemical interaction (RapidFire MS assay) EUB0000232b LIMK1
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000285b LIMK1
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000232b LIMK1
Inhibition of LIMK1 (unknown origin) at 1.0 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of LIMK1 (unknown origin) at 1 uM relative to control
Inhibition of human LIMK1 at 1 uM relative to control
Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureFire assay
Assay data:11 Active, 11 Activity ≤ 1 µM, 17 Tested
Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition by NanoBRET assay
Assay data:12 Active, 11 Activity ≤ 1 µM, 17 Tested
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