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Inhibition of human recombinant LIMK2
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of LIMK2 (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of LIMK2 (unknown origin) in presence of ATP at 200 uM
Assay data:8 Active, 6 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of LIMK2 (unknown origin) in presence of ATP at 25 uM
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of human LIMK1 (312 to 638 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid method
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
In Vitro Assay from US Patent US20230312576: "4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER"
Assay data:118 Active, 114 Activity ≤ 1 µM, 118 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Biochemical interaction (RapidFire MS assay) EUB0000285b LIMK2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Affinity Biochemical interaction (RapidFire MS assay) EUB0000232b LIMK2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000285b LIMK2
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000232b LIMK2
Inhibition of wild-type human full length LIMK2 (M1 to P638 residues) expressed in bacterial expression system by Kinomescan method
Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureFire assay
Assay data:11 Active, 11 Activity ≤ 1 µM, 17 Tested
Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition by NanoBRET assay
Assay data:12 Active, 12 Activity ≤ 1 µM, 17 Tested
Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by RapidFire Mass Spectrometry kinase assay
Assay data:17 Active, 13 Activity ≤ 1 µM, 21 Tested
Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by RapidFire Mass Spectrometry kinase assay
Assay data:17 Active, 14 Activity ≤ 1 µM, 21 Tested
Inhibition of GST tagged recombinant LIMK2 (unknown origin) using cofilin as substrate by by SDS-PAGE analysis
Inhibition of his6 tagged LIMK2 (unknown origin) expressed in baculovirus-infected Sf9 cells measured after 1 hr in presence of ATP by fluorescence based analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human glutathione S-transferase-tagged LIMK2 (312 to 638 residues) expressed in baculovirus-infected Sf9 cells incubated for 60 mins by radiometric scintillation counting analysis
Binding affinity to human wild-type full length LIMK2 (M1 to P638 residues) expressed in bacterial expression system assessed as dissociation constant by Kinomescan method
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