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In Vitro PDHK1 Activity Assay from US Patent US20240140933: "OXOINDOLINE COMPOUND FOR THE TREATMENT OF INFLAMMATORY DISEASES OR CANCER"
Assay data:63 Active, 63 Activity ≤ 1 µM, 63 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PDK1 Invitrogen Lab (UK) kinase screen (BI)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of recombinant full length His-tagged human PDK1 expressed in baculovirus expression system by FRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PDK1 (unknown origin)
Inhibition of human recombinant PDHK1 using KKKYHGHSMSDPGVSYRT as substrate incubated for 40 mins in presence of Mg/ATP mix by [gamma-32P]-ATP based scintillation counting analysis
SummaryPubMed CitationRelated BioAssays by Target
Selectivity interaction (Kinase panel (University of Dundee)) EUB0000169b PDK1
Selectivity interaction (Kinase panel (enzymatic assay)) EUB0000153b PDK1
Inhibition of PDK1 (unknown origin) at 50 nM by Z'LYTE screening method relative to control
Assay data:3 Tested
Inhibition of human PDK1 assessed as residual activity at 30 uM relative to control
Inhibition of human recombinant GST-fused PDK1 expressed in Sf9 cells incubated for 30 mins in presence of [gamma-33P]ATP by scintillation counter analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PDK1 (unknown origin) by SelectScreen kinase assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of PDK1 in human BT-474 cells assessed as reduction in AKT phosphorylation at T308 residue incubated for 2 hrs
Assay data:3 Active, 3 Tested
Inhibition of PDK1 (unknown origin) at 0.5 uM assessed as competition rate relative to control
Inhibition of PDK1 (unknown origin) at 0.5 uM relative to control
Inhibition of PDK in human A-375 cells assessed as reduction in PDH phosphorylation at ser293 residue at 5 to 20 uM after 24 to 48 hrs
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human PDK1 at 1 uM relative to control
PDK1(h) Kinase panel
PDHK4(h) Kinase panel
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