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Inhibition of human caspase 3 using Z-Phe-Arg-AMC as substrate incubated for 30 mins by FRET assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of caspase 3/7 in human 22Rv1 cells by Caspase-Glo reagent based analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of caspase-7 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of caspase-3 (unknown origin)
Binding affinity to human recombinant caspase 3 at 0.3125 to 5 uM measured after 400 secs by Surface plasmon resonance method
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Binding affinity to human caspase 3 in human MDA-MB-231 cells at 5 uM measured after 3 hrs by Cellular thermal shift assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of caspase 3 in human MDA-MB-231 cells measured after 48 hrs by Plate reader method
Assay data:8 Active, 38 Tested
Activation of caspase 3 (unknown origin)
Assay data:2 Tested
Inhibition of human caspase 3 using Ac-Asp-Glu-Val-Asp-pNA as substrate by FRET assay
Activation of caspase-3/7 activity in human 518A2 cells at 25 nM preincubated for 24 hrs followed by caspase-3/7 fluorogenic substrate addition and measured after 60 mins by fluorescence assay
Assay data:7 Active, 7 Tested
Activation of caspase-3/7 activity in human 518A2 cells at 1 uM preincubated for 6 hrs followed by caspase-3/7 fluorogenic substrate addition and measured after 60 mins by fluorescence assay
Assay data:1 Active, 1 Tested
Inhibition of human caspase-3 using Ac-Asp-Glu-Val-Asp-pNA as substrate incubated for 60 mins by FRET assay
Activation of caspase 3/7 in human MV4-11 cells incubated for 6 hrs by Caspase-Glo 3/7 reagent based microplate reader analysis
Assay data:32 Active, 27 Activity ≤ 1 µM, 33 Tested
Inhibition of Caspase Activity Assay from US Patent US11447497: "(S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzymatic Inhibition of UAWJ9-36-1 and UAWJ9-36-3 against the Mpro's from Seven Human Coronaviruses from Article 10.1021/acsptsci.1c00099: "Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir."
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition Assay from US Patent US9345789: "Specific inhibitors and active site probes for legumain"
Assay data:3 Active, 3 Activity ≤ 1 µM, 5 Tested
Caspase Catalytic Activity Assay from Article 10.1016/j.chembiol.2017.02.003: "Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors."
Assay data:6 Active, 4 Activity ≤ 1 µM, 8 Tested
Inhibition Assay from US Patent US9045524: "Selective caspase inhibitors and uses thereof"
Assay data:17 Active, 17 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Fluorometric Enzymatic Assay from US Patent US9045524: "Selective caspase inhibitors and uses thereof"
Assay data:15 Active, 9 Activity ≤ 1 µM, 26 Tested
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