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Summary
In Vitro Kinase Assay - Inhibition of ALK1/2/3/4/5/6 Kinases from US Patent US11702401: "Compounds and methods of use"
Assay data:33 Active, 32 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Luciferase Reporter Gene Assay for ALK2 and TGFbeta Activity from US Patent US11654147: "ALK2 inhibitors and methods for inhibiting BMP signaling"
Assay data:149 Active, 1 Activity ≤ 1 nM, 165 Activity ≤ 1 µM, 170 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000702a BMPR1B
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human wild type partial length BMPR1A (Q214 to I532 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ALK3 (unknown origin)
Assay data:23 Active, 13 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant ALK3 (198 to 525 residues) expressed in baculovirus-infected insect cells by ADP-Glo kinase assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of GST-tagged human recombinant ALK3 expressed in insect cells using casein as substrate in presence of [gamma-32P]ATP incubated for 45 mins by Microscint-20 scintillation counting analysis
Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation activity using peptide substrate in presence of ATP and measured after 1 hrs by HTRF assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Binding affinity to wild type ALK3 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control
Binding affinity to wild type ALK6 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control
Inhibition of wild type ALK6 (unknown origin) assessed as enzymatic activity using chemiluminescent substrate by ADP-Glo assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of wild type ALK3 (unknown origin) assessed as enzymatic activity using chemiluminescent substrate by ADP-Glo assay
BMPR1B DiscoveRx kinase panel
BMPR1A DiscoveRx kinase panel
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