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Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microplate reader analysis
Assay data:33 Active, 30 Activity ≤ 1 µM, 38 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microplate reader analysis
Assay data:28 Active, 13 Activity ≤ 1 µM, 38 Tested
Inhibition of Tryptophan Hydroxylase Activity from US Patent US11407763: "Tryptophan hydroxylase inhibitor and pharmaceutical composition including same"
Assay data:22 Active, 18 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Enzyme Activity Assay from US Patent US11028104: "Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same"
Assay data:42 Active, 39 Activity ≤ 1 µM, 42 Tested
In Vitro Enzyme Activity Assay from US Patent US10683309: "Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same"
In Vitro Enzyme Activity Assay from US Patent US10214530: "Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same"
Assay data:48 Active, 39 Activity ≤ 1 µM, 57 Tested
Biochemical In Vitro Assay from US Patent US9765092: "Tricyclic piperidine compounds"
Assay data:442 Active, 442 Activity ≤ 1 µM, 442 Tested
Inhibition of Tryptophan hydroxylase 1 (unknown origin) incubated for 4 hrs by fluorescence based assay
Assay data:11 Active, 10 Activity ≤ 1 µM, 12 Tested
Inhibition of Tryptophan hydroxylase 1 (unknown origin) at 10 uM incubated for 4 hrs by fluorescence based assay
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Tryptophan hydroxylase 1 (unknown origin) at 1 uM incubated for 4 hrs by fluorescence based assay
Assay data:25 Tested
Inhibition of Tryptophan hydroxylase 1 (unknown origin)
Assay data:1 Tested
Inhibition of TPH2 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of TPH1 (unknown origin)
Assay data:38 Active, 37 Activity ≤ 1 µM, 38 Tested
Human L-Tryptophan hydroxylase 1 (Amino acid hydroxylases)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Assay data:65 Active, 60 Activity ≤ 1 µM, 67 Tested
Inhibition of TPH1 (unknown origin) using L-tyrosine as substrate after 20 mins
Assay data:34 Active, 16 Activity ≤ 1 µM, 37 Tested
Binding affinity to TPH-1 (unknown origin) by SPR analysis
Assay data:1 Active, 1 Tested
Inhibition of TPH-2 in rat PC12 cells assessed as downregulation of TPH-2 mRNA expression at 10 uM after 24 to 48 hrs by qRT-PCR analysis
Inhibition of TPH-2 in rat PC12 cells assessed as downregulation of TPH-2 protein expression at 10 uM by ELISA
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